Biochemistry: BCHM 461

Fall 2024

Course meets in Chem 1402, TuTh 12:30-1:45 pm
Professor: David Fushman
Office Hours: (tentative) Wednesday 4:00 - 5:30 pm (via zoom)
E-mail: fushman@umd.edu

Syllabus

Textbooks

Required:
Lehninger Principles of Biochemistry, 8th edition by Nelson and Cox (earlier editions will work, too)
Recommended:
The Absolute, Ultimate Guide to Lehninger Principles of Biochemistry, 6th edition by Osgood and Ocorr
Biochemistry by Voet and Voet
 
Assignments:
Reading and problem assignments are from Lehninger Principles of Biochemistry
Date Reading Problems Q&A
12/16 FINAL EXAM: 4:00-6:00pm; Rm 1402 Bring your calculator.    
12/05 Ch.6.5: 225-232. Study for the final exam Last Lecture. The second part will be devoted to review session for the upcoming final exam. Bring your questions. Topics that were covered in the course and could be on the final exam will be listed here.  
12/03 Ch.6.3: pp. 194-195; 6.5: pp. 213-216 Solutions to Q#5 problems are in today's lecture slides. Solutions to midterm exam #2 problems are posted below.    
11/26 Ch.6.3: pp. 195-197; 6.4: pp. 203-208 Graded Quiz #5 is due by 11:59pm on Monday Dec.2.   
11/21 Midterm Exam #2 Your (last) Graded Quiz #5 is here. It's due by 11:59pm on Monday Dec.2.   
11/19 Ch.6.3, pp. 188-194; 197-203 Ch.6, Problems 8-10, 12, 14. Prepare for the midterm Exam #2. Review session: Wednesday Nov 20 at 6pm via zoom.  
11/14 Ch.6.2: pp 177-188; Ch.6.3: pp.188-194 Worked examples 6-1 and 6-2 in Ch.6.3. Follow the derivation of the Michaelis-Menten equation in the textbook (pp. 190-191) and on the lecture slides. Problems from a previous midterm exam #2 are here.. Review session: Wednesday Nov 20 at 6pm via zoom. Solutions to problems from a previous midterm exam #2 are here.. Answers/solutions to graded Quiz #4 problems are here. 
11/12 Ch.5.1 to the end (pp.160-164),Ch.6.1-6.2: pp 177-188 Ch.5: Problems 8-11; Ch.6: Problems 1-4,6.    
11/07 Ch.5.1: pp 148-160 Ch.5: Problems 2,6,7. Your Graded Quiz #4 is here. It's due on Wednesday Nov 13 by 11:59pm Answers to graded Quiz #3 problems are here. 
11/05 Ch. 4.5, pp. 139-142; Ch.5.1: pp 150-152. Ch.5: Problems 1,3-5. Worked examples 5-1, 5-2. Also answer questions highlighted yellow on the lecture slides.  
10/31 Ch.4.5, pp. 137-139, Fig.4-31. Lecture slides on NMR. Watch youtube videos listed on slide #6. The distribution and statistics of the Exam #1 scores and the current scores are posted in the Table below. 
10/29 Ch.4.5, pp.136-137, Box 4-30 lecture slides on X-ray crystallography and small-angle scattering. Answer questions highlighted in yellow in lecture slides.   
10/24 Ch.4.2, p.116,Box 4-9, Ch.4.5 pp.136-137, Box 4-30 + lecture slides Refresh your knowledge of basic trigonometric functions: sine and cosine and of complex numbers. Your graded Quiz #3 is here. It is due by 11:59 pm on Wednesday Oct 30.   Solutions to Exam #1 problems are posted in the Table below together with the statistics of the exam scores and current scores  
10/22 Ch.4.4: pp 128-135(through the end of Ch.4.4) + lecture slides Ch.4: Problems 13,14.    
10/17 Ch.4.3: to the end (pp. 126-128). Problems: 7-10. If you haven't done them yet, do the PyMOL-related homework questions from the previous lecture (also included on slide 1 of this lecture)  
10/15 Ch.4.3, pp. 116-125 (all about tertiary structure). Homework assignments related to PyMOL use are on the lecture slides. A brief list of PyMOL operations and commands is here and on ELMS    
10/10 Midterm Exam #1 After the exam: download and install PyMOL. Brief step-by-step instructions on how to download the free educational version of the program have been emailed to you, and also posted on ELMS. Bring your laptops to the class on Tuesday.    
10/08 Ch.4.2 to the end & Lecture slides Prepare for the midterm exam  Video recording of the review session is on ELMS, under Files. 
10/03 Ch.4.1-4.2 (alpha-helix). Ch.4: Problems 1-4,11. Solutions to practice problems from a previous midterm exam #1 are here. Pleaase try solving these problems youself before looking at my solutions. Detailed answers/sulutions to graded quiz #2 questions are here.    Review session for the upcoming exam will take place at 6pm on Wednesday via zoom. Bring your questions.
10/01 Ch.3.4, pp. 90-to the end. Ch.3: Problems 20-23, 26. + Homework problems I-III from the lecture slides.  Practice problems from a previous midterm exam #1 are here..
09/26 Ch.3.3 pp 88-90 (finish Ch. 3.3) Ch.3, Problems 19, 25. Don't forget to submit your Graded Quiz #2.  
09/24 Ch.3.3, pp. 83-87 Ch.3, Problems 15,17,18. Your Graded Quiz #2 is here. It is due by 11:59 pm on Monday Sept 30.   Answers/solutions to Graded Quiz #1 problems are here.
09/19 Ch. 3.2: pp.80-83 Ch.3, Problems: 9-14 + questions in yellow boxes on the lecture slides.  
09/17 Ch.3.1, pp.76-80 Ch.3, Problems: 1,3-5,8. + answer questions in yellow boxes on the lecture slides. The first midterm exam will be given on Thursday October 10,  
09/12 Ch.3.1, pp. 70-76 (till uncommon amino acids), Including Box 3-1 Memorize the 20 amino acids.  
09/10 Ch.2: read to the end Ch.2, Problems: 10-14,16,19-20,24,26,28. Here is your graded Quiz #1. It is due by 11:59 pm on Monday Sept 16.  
09/05 Finish Ch. 2.1; read Ch. 2.2 pp. 53-59 Ch.2, Prs: 3-5,7-8,11. Answer highlighted questions on lecture slides.  
09/02 Finish Bioenergetics: Ch. 1.3. New material: Ch. 2.1, pp: 43-53 (read through the end of 2.1. Some interactions not covered today will be covered in the next lecture). Ch.2, Pr. 1. If you haven't done them yet, do the homework problems from the previous lecture.  
08/29 Ch.1.3 (pp.20-27); Ch.13.3 (pp.465-472) Ch.13: Problems #2-5. Also Homework Problems I-IV and Questions in Lecture_2 slides (ELMS).  
08/27 Ch.1, pp. 1-20 Ch.1: Problems: 2,7,9; Figure 1-14: refresh your memory of the chemical properties of the functional groups shown in that figure. Please answer the Semester-start assessment quiz in the Lecture 1 slides posted on ELMS.  
08/27 Welcome to the Fall 2024 BCHM461 course!    
Exam # 1: Exam # 2: Final Exam:
Statistics Statistics Statistics
Solutions Solutions Solutions
     

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