During my practicum, I had the opportunity to work at the physical measurement laboratory at the National Institute of Standards and Technology (NIST). Under the mentorship of Dr. Joseph Robertson, I conducted research on the design of a DNA origami construct to secure gold nanoparticles within precise geometry to the pore of a membrane protein. This experience provided me with valuable insights into the world of scientific research and its practical applications. In this summary, I will discuss my practicum site, the tasks I performed, the scientific knowledge I gained, and the impact of this experience on my future plans.I conducted my practicum at the physical measurement laboratory at NIST, a renowned institution dedicated to advancing measurement science and technology. NISTs cutting-edge research facilities and expert scientists provided an ideal environment for my research on DNA origami and nanoparticle assembly.
I discovered the opportunity at NIST through various research internship websites and academic networks. After applying and undergoing an interview process, I was fortunate to be brought on as a guest researcher. When searching for a practicum site, it is essential to explore reputable institutions and research groups aligned with your interests. Utilizing online platforms, networking with professors, and directly contacting potential supervisors can greatly enhance your chances of finding a suitable site. During my time at NIST, I focused on the design and assembly of DNA origami constructs to precisely position gold nanoparticles within the pore of a membrane protein. I conducted literature reviews, designed DNA origami sequences, performed experiments, and analyzed data using various biochemical techniques and imaging technologies. Additionally, I collaborated with other researchers and attended lab meetings to share progress and receive feedback.
Working on this project provided me with a deep understanding of DNA origami design principles, nanoparticle assembly techniques, and the interaction between nanoparticles and membrane proteins. I gained practical knowledge of experimental procedures, data analysis, and troubleshooting. Furthermore, I developed critical thinking skills and learned how to apply scientific principles to solve complex problems.My practicum experience highlighted the practical connections between science and society. By working on a project with potential applications in nanotechnology and drug delivery systems, I realized how scientific research contributes to technological advancements and improves people's lives. This appreciation for the practical implications of scientific research has inspired me to pursue interdisciplinary collaborations and contribute to society through my future endeavors.
Although I thoroughly enjoyed my research in DNA origami, this practicum experience influenced my future plans. I have decided to shift my focus to computer science, as I discovered a passion for data analysis, algorithm development, and machine learning during the research process. My exposure to computational methods in bioinformatics and data-driven research motivated me to explore the intersection of computer science and biology. One of the biggest challenges of this research was developing a python program to simulate the dispersion of heat as a function of particle count, size, and distance from the pore.
While my practicum experience shifted my academic focus, it also impacted my future career plans. I now intend to pursue a career that combines computer science with biological research, such as computational biology or bioinformatics. This experience broadened my perspective on potential career paths and reinforced the importance of interdisciplinary collaboration in addressing complex scientific challenges.My practicum experience at NISTs physical measurement laboratory was an invaluable opportunity to engage in scientific research and explore the practical applications of DNA origami and nanoparticle assembly. Through this experience, I gained knowledge, skills, and a deeper understanding of the connections between science and society. While my future plans have been modified to pursue computer science, this practicum experience will undoubtedly shape my academic and career trajectory by fostering interdisciplinary thinking and a passion for innovative research.