Syllabus

Biological and Chemical Detection

Fall 2007

Instructor:

Nam Sun Wang

Class Hour: Tue 7:00-9:40pm, ENG1102

Office Hours: MWF 11:00am-12:00noon, Rm 1208 Chemical Engineering Bldg. or contact instructor via e-mail.

Required Textbook:

None

Other Useful Books:

Mathcad User's Manual & Software (any edition)

Prerequisites:

Admission into the Professional Masters Degree Program or permission from the Instructor.

The overall goal of the course is to provide a survey of the various software and hardware aspects associated with chemical and biological detection. Theories and computational methods in modeling and data fitting. Possible topics include: sensor and transducer components, computer data acquisition and analysis, multivariate regression, calibration, filtering, and sampling. Examples will be drawn from military (chemical & biological warfare), agricultural (food safety), environmental monitoring, and medical applications.

Sensor Data Analysis (Chemometrics)
- Calibration
- Scaling & Transformation
- Variance & Standard Deviation, Correlation
- Linear Regression
- Goodness of Fit
- Multiple Linear Regression
- Nonlinear Regression
- Principal Component Analysis
- Partial Least Squares
- Neural Networks
- Discriminant Analysis
- Classification
- Calibration Transfer
- Sensor Integration & Data Fusion
Noise and Error Handling
- Filtering
- Kalman Filter
- Gross Error Detection & Rectification
Data Acquisition
- A/D & D/A, RS232
- Hardware Interface
- Software Interface
- Signal Conditioning
- Noise Reduction
- Sampling Rate, Aliasing
- Response Time, Transient & Frequency Response
- On-Line Process Monitoring
Sensors/Transducers
- Temperature
- Pressure, Force, Piezoelectric
- Displacement/Proximity
- Physical Measurements
  - Redox, pH, Dissolved Oxygen
  - Spectroscopy (UV, Visible, NIR, IR, Acoustics)
  - GC/MS
- Chemical Sensors
  - Electrochemical
  - Dielectric (Capacitance, Conductance)
  - Field Effect Transducers (FET) (ISFET, MOSFET, etc.)
  - Surface Acoustic Wave (SAW) Devices
  - Reversible Chemisorption
- Biochemical & Biological (Biosensors)
  - Immunoassay
  - ELISA
  - Antibody-Antigen Interaction
  - Protein/Enzyme Immobilization
  - Enzyme Electrode
  - Chemiluminescence, Bioluminescence
  - Labels (Fluorophores, Chromophores, Radioactive)
  - Conjugationof Labels to Protein
  - DNA Hybridization & Probes
  - DNA Chips
- Optical
  - Light Source
  - Fiber Optics
  - Gratings/AOTF
  - Detectors, Diode Arrays, CCD
- Sensitivity
- Selectivity
Sampling
- Air, Gas
- Water, Liquid
- Solid
- Manual & Automated
- Flow Injection
- Sample Preparation
- Sample Concentration
- Experimental Design
Applications (Guest/Student Speakers)
- Military (e.g., Chemical & Biological Warfare Agents, Explosives)
- Chemical Processing Industries
- Agricultural (food safety, forage)
- Environmental Monitoring
- Pharmaceutical
- Medical Diagnostics
- Industrial Safety

The actual coverage to an extent will be determined by student preference. Please give me input at any time to modify the topics to be covered.

Grading:

Oral Presentation (11/27-12/04)	50%
Written Project Report (Due 12/11)	50%

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Biological and Chemical Detection -- Syllabus
Forward comments to:

Nam Sun Wang

Department of Chemical Engineering

University of Maryland

College Park, MD 20742-2111

301-405-1910 (voice)

301-314-9126 (FAX)