Open navigation

Our Research Group

At the Amplified Molecular Sensors Lab, we aim to overcome the challenges that are preventing the realization of the next generation of biosensing and diagnostic systems. In particular, we emphasize the development and application of novel amplification strategies to add orders of magnitude improvement to chemical and biomolecular sensing, while at the same time improving the simplicity and usability of sensors and diagnostic systems. Take a look at our most recent publications.

Projects

Inkjet-Printed SERS Substrates

Inkjet-Printed SERS Substrates

As a bio/chemical sensing technique, surface enhanced Raman spectroscopy (SERS) offers sensitivity comparable to that of fluorescence detection while providing highly specific information about the analyte. Although single molecule identification with SERS was demonstrated over a decade ago, today a need exists to develop practical solutions for point-of-sample and point-of-care SERS systems. We recently demonstrated the fabrication of SERS substrates by inkjet printing silver and gold nanostructures onto paper and other similar membranes, achieving detection limits comparable to conventional nanofabricated substrates. Furthermore, we have leveraged the fluidic properties of paper to enhance the performance of the SERS devices while also enabling unprecedented ease of use, which is critical for extending chemical and biological analytics from central labs out into the field. We are currently investigating the use of these paper-based SERS sensors for both chemical and biological sensing applications.

  • Stephen M. Restaino and Ian M. White, A critical review of flexible and porous SERS sensors for analytical chemistry at the point-of-sample, Analytica Chimica Acta, in press, 2019, DOI:10.1016/j.aca.2018.11.057

  • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

  • Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

  • Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

  • Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

  • Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

  • Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

Hands-free single-tube assays

Hands-free single-tube assays

Ease-of-use, which in particular includes hands-free operation, is the key to moving diagnostics away from the central lab. Our group invents new approaches to eliminate precise operational steps from sample preparation and assay operation in order to make diagnostics easier to use.

  • John P. Goertz, Kerry DeMella, Benjamin Thompson, Ian M. White, and Srinivasa Raghavan, Responsive capsules that enable hermetic encapsulation of contents and their thermally triggered burst-release, Materials Horizons, in press, 2019. DOI:10.1039/c9mh00309f.

  • John P. Goertz, Kenya Colvin, Andrew Lippe, John Daristotle, Peter Kofinas, and Ian M. White, Multi-Stage Chemical Heating for Instrument-Free Biosensing, ACS Applied Materials and Interfaces, 10, 33043–33048, 2018. DOI:10.1021/acsami.8b11611

  • John P. Goertz and Ian M. White, Phase-change partitions for thermal automation of multi-step reactions, Analytical Chemistry, 90, 3708–3713, 2018. DOI:10.1021/acs.analchem.7b05400.

  • Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017 DOI:10.1021/acs.analchem.7b00274

  • Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

Functional Nucleic Acids for Biosensing

Functional Nucleic Acids for Biosensing

We utilize aptamers and catalytic nucleic acids as biorecognition and reporter elements in biosensor systems. We have invented an exponentially amplified photocatalyzed reaction that enables sensitive, naked-eye detection of hemin-binding, HRP-mimicking DNAzymes ("peroxidymes") with a dynamic range of five orders of magnitude. This reaction,PARCR, will facilitate use of peroxidymes as reporters in point-of-care assays by simplifying detection and minimizing manual steps.

  • Alessandra C. Zimmermann, Ian M. White, and Jason D. Kahn, "Nucleic acid-cleaving catalytic DNA for sensing and therapeutics, Talanta, in press, 2020. DOI:10.1016/j.talanta.2019.120709

  • John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Visible Detection of a Catalytic Reporter, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.

Rapid Phenotypic Detection of Antibiotic Resistance

Rapid Phenotypic Detection of Antibiotic Resistance

Extended spectrum beta-lactamase resistance is best detected phenotypically, but this requires multiple rounds of culture. We are developing approaches to reduce the time-to-result in order to improve patient outcomes and antimicrobial stewardship.

  • Hieu T. Nguyen, Shweta Ganapati, David Watts, Imaly A. Nanayakkara, Philip DeShong, Ian M. White, A new trimodal phenotypic reporter of extended-spectrum beta-lactamase activity, ACS Infectious Disease, in press, 2019. DOI:10.1021/acsinfecdis.9b00138.

  • People

    Principal Investigator

    Dr. Ian White

    Dr. Ian White

    Associate Chair and Director of Undergraduate Studies
    Fischell Department of Bioengineering
    2216 Jeong H. Kim Engineering Bldg.
    University of Maryland
    College Park, MD 20742
    301-405-6230
    Google Scholar


    Joined the University of Maryland in 2008
    Post-doc: University of Missouri, Life Sciences Center (2005–2008)
    Ph.D. Electrical Engineering, Stanford University (2002)

    Senior lab members

    Shannon Hilton

    Shannon Hilton, Post-doctoral Associate

    Bio:

    • T32 fellowship in Cancer Biology
    • Joined White Lab in 2019
    • Ph.D. in Chemistry, Arizona St. University (2019)
    Micaela Everitt

    Micaela Everitt, Graduate Student

    Bio:

    • NSF Fellow
    • Joined White Lab in 2019
    • B.S. in Biomedical Engineering, University of Washington (2018)
    David Boegner

    David Boegner, Graduate Student

    Bio:

    • Joined White Lab in 2020
    • B.S. in Bioengineering, University of Maryland (2020)
    • Undergraduate Students

      Alana Tillery

      Alana Tillery

      Bio:

      • Banneker/Key Scholar
      • Philip Merrill Scholar
      • NSF LSAMP Bridge Scholar
      • Joined White Lab in 2019
      • Bioengineering Class of 2021
      Nikita Singh

      Nikita Singh

      Bio:

      • President's Scholarship
      • ASPIRE scholar
      • Joined White Lab in 2019
      • Bioengineering Class of 2022
      Martha David

      Martha David

      Bio:

      • LSAMP Scholar
      • Clark Opportunity Transfer Scholarship
      • Joined White Lab in 2020
      • Bioengineering Class of 2021

      Previous Lab Members

      Previous Post-Doctoral Associates

      Dr. Jeffrey Burke

      Dr. Jeffrey Burke

      Principal Engineer at Circulomics Inc
      Postdoctoral Research Associate in the White Lab, 2011-2013

      Dr. I-Jane Chen

      Dr. I-Jane Chen

      Staff Engineer at Becton Dickonson
      Former R&D Engineer, Microfluidics Team at Caliper Life Sciences
      Postdoctoral Research Associate in the White Lab, 2008-2011

      Previous Graduate Students

      Imaly Nanayakkara

      Imaly Nanayakkara

      LinkedIn |

      Bio:

      • Joined White Lab in 2015
      • Outstanding Graduate Researcher, Fischell Dept. of Bioengineering, 2019
      • M.S. in Biomedical Engineering, Univerity of California - Irvine (2014)
      • B.S. in Biomedical Engineering, Boston University (2012)

      White Lab Publications:

      • Imaly A. Nanayakkara and Ian M. White, Demonstration of a quantitative triplex LAMP assay with an improved probe-based readout for the detection of MRSA, Analyst, 144, 3878 - 3885, 2019. DOI:10.1039/C9AN00671K.
      • Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017 DOI:10.1021/acs.analchem.7b00274
      • Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006
      Hieu Nguyen

      Hieu Nguyen

      LinkedIn |

      Bio:

      • NSF Fellow
      • Joined White Lab in 2015
      • B.A. in Biology, Brown University (2009)

      White Lab Publications:

      • Hieu T. Nguyen, Shweta Ganapati, David Watts, Imaly A. Nanayakkara, Philip DeShong, Ian M. White, A new trimodal phenotypic reporter of extended-spectrum beta-lactamase activity, ACS Infectious Disease, in press, 2019. DOI:10.1021/acsinfecdis.9b00138.

      Alessandra Zimmermann

      Alessandra Zimmermann

      LinkedIn |

      Bio:

      • Joined White Lab in 2015
      • B.S. in Chemistry with Biology minor, Carnegie Mellon (2013)

      White Lab Publications:

      • Alessandra C. Zimmermann, Ian M. White, and Jason D. Kahn, "Nucleic acid-cleaving catalytic DNA for sensing and therapeutics, Talanta, in press, 2020. DOI:10.1016/j.talanta.2019.120709

      John Goertz

      John Goertz

      LinkedIn | Google Scholar |

      Post-doc, Imperial College London
      Doctoral Student in the White Lab, 2013-2018

      White Lab Publications

      • John P. Goertz, Kerry DeMella, Benjamin Thompson, Ian M. White, and Srinivasa Raghavan, Responsive capsules that enable hermetic encapsulation of contents and their thermally triggered burst-release, Materials Horizons, in press, 2019. DOI:10.1039/c9mh00309f.
      • John P. Goertz, Kenya Colvin, Andrew Lippe, John Daristotle, Peter Kofinas, and Ian M. White, Multi-Stage Chemical Heating for Instrument-Free Biosensing, ACS Applied Materials and Interfaces, 10, 33043–33048, 2018. DOI:10.1021/acsami.8b11611
      • John P. Goertz and Ian M. White, Phase-change partitions for thermal automation of multi-step reactions, Analytical Chemistry, 90, 3708–3713, 2018. DOI:10.1021/acs.analchem.7b05400.
      • John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Visible Detection of a Catalytic Reporter, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.
      Dr. Stephen Restaino

      Dr. Stephen Restaino

      LinkedIn

      Senior Research Engineer, Maryland Development Center
      Doctoral Student in the White Lab, 2012-2017

      White Lab Publications:

      • Stephen M. Restaino and Ian M. White, A critical review of flexible and porous SERS sensors for analytical chemistry at the point-of-sample, Analytica Chimica Acta, in press, 2019, DOI:10.1016/j.aca.2018.11.057

      • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035
      Qian Zhang

      Qian Zhang

      Visiting Doctoral Student in White Lab 2015-2016

      Ken Sharp

      Ken Sharp

      Production Technician at Trevigen
      Masters Student in the White Lab, 2015-2016

      Sean Virgile

      Sean Virgile

      Co-founder and CFO of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
      Doctoral Student in the White Lab, 2010-2015

      Dr. Kunal Pandit

      Dr. Kunal Pandit

      Research Engineer at New York Genome Center
      Doctoral Student in the White Lab, 2012-2015

      Dr. Eric Hoppmann

      Dr. Eric Hoppmann

      Data Scientist at Earth Networks
      Co-founder and Former CEO of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
      Doctoral Student in the White Lab, 2008-2013

      Dr. Soroush Yazdi

      Dr. Soroush Yazdi

      Senior Biomedical Engineer at Medtronic
      Doctoral Student in the White Lab, 2009-2013

      Dr. Wei "VeeMoon" Yu

      Dr. Wei "VeeMoon" Yu

      Co-founder and Lead Scientist of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
      Postdoctoral Research Associate in the White Lab, 2013-2014
      Doctoral Student in the White Lab, 2008-2013

      Dr. Katayoon Saadin

      Dr. Katayoon Saadin

      Complex Microbial Systems Group at the National Institute of Standards and Technology
      Former Clinical Research Associate at LifeBridge Health
      Former Biotechnology Consultant for the University System of Maryland
      Doctoral Student in the White Lab, 2009-2012

      Undergraduate Students

      Connor Hall

      Aviva Borison

      Aliyah Taule

      Andrew Lippe

      Kenya Colvin

      Megan Dang

      Adam Berger

      Eden Paul

      Divya Jain

      Carolyn Lane

      Kristen Giles

      Aaron Rubinstein

      Marina Shumakovich

      Neerav Patel

      Amanda Dols

      Nathalie Dagenais

      Jenni Jung

      Jon Eskin

      Steve Robinson

      Helen Ji

      Jeff Misiewicz

      Ashu Poudyal

      Amin Asemani

      Dave Gaddes

      Naomi Goldstein

      Farnoosh Farahi

      News

      (July 1, 2020) Shannon Hilton was awarded a T32 NIH Training Fellowship

      (June 25, 2020) Alana Tillery was named a Philip Merril Presidential Scholar.

      (June 10, 2020) Alana Tillery was presented with an Extraordinary Service Award by BIOE for her service at COVID-19 testing sites and a local ER.

      (May 18, 2020) Alana Tillery was received the Outstanding BIOE Junior Award.

      (August 19, 2019) Shannon Hilton (Ph.D., Arizona St. Univesrity) has joined our research group. Welcome, Shannon!

      (August 9, 2019) Alessandra Zimmermann passed her Ph.D. dissertation defense! Congratulations!

      (July 24, 2019) Hieu Nguyen passed his Ph.D. dissertation defense! Congratulations!

      (April 17, 2019) Connor Hall was given the Bioengineering Department's Outstanding Junior Award.

      (April 9, 2019) Micaela Everitt was awarded the National Science Foundation's Graduate Research Fellowship.

      (April 2, 2019) Imaly Nanayakkara passed her Ph.D. dissertation defense! Congratulations!

      (March 12, 2019) Micaela Everitt (BS, Univ. of Washington) has joined our research group. Welcome, Micaela!

      (February 1, 2019) Our lab received an R01 (a collaboration with Don DeVoe and Steve Jay) from NIGMS to develop a new tool for exosome/miRNA-based biomarker discovery.

      (January 13, 2019) Former grad student John Geortz received an F32 post-doctoral fellowship while at Imperial College London. Congratulations!

      (December 20, 2018) Sean Virgile passed his M.S. dissertation defense! Congratulations!

      (September 12, 2018) Imaly Nanayakkara won the BIOE graduate researcher of the year award.

      (July 6, 2018) John Goertz passed his Ph.D. dissertation defense! Congratulations!

      (February 9, 2018) Kenya Colvin has been awarded the ASPIRE undergraduate research fellowship to continue her research in spring 2018.

      (November 13, 2017) Diagnostic anSERS, along with our paper SERS technology, has been acquired by Metrohm Raman.

      (October 26, 2017) Stephen Restaino passed his Ph.D. dissertation defense! Congratulations!

      (October 26, 2017) Adam Berger and Megan Dang graduate with Bachelor of Science degrees in Bioengineering. Congratulations, and good luck on your future endeavors!

      (April 14, 2017) Adam Berger's thesis was selected as a winner in the 2017 Best Honors Thesis category for the Winston Family Honors Best Student Paper Awards.

      (April 12, 2017) Adam Berger successfully defended his BIOE Honors Thesis.

      (April 3, 2017) Imaly Nanayakkara successfully defended her Ph.D. proposal!

      (February 23, 2017) Adam Berger has been named the recipient of the Fischell Outstanding Senior Award.

      (February 1, 2017) Adam Berger has been named the recipient of the A. James Clark School of Engineering Dean’s Award, the most prestigious award in the college.

      (August 24, 2016) Adam Berger has been named a Philip Merrill Presidential Scholar in recognition of his academic excellence.

      (August 10, 2016) Adam Berger has received the BMES Undergraduate Design and Research Award for his work on therapeutic drug monitoring with paper SERS devices. The award will be presented at the 2016 BMES conference.

      (April 25, 2016) Megan Dang has been awarded the SEEDS undergraduate research fellowship from summer 2016 and the 2016-2017 academic year.

      (April 22, 2016) Kenya Colvin has been awarded the ASPIRE undergraduate research fellowship to continue her research in summer 2016.

      (April 7, 2016) Adam Berger has been awarded the Dinah Berman Memorial Award for his combined academic excellence and service to the Clark School.

      (April 7, 2016) Adam Berger has been awarded the Fischell Department of Bioengineering Outstanding Junior Award.

      (April 6, 2016) Adam Berger has won a UMD HHMI summer research fellowship!

      (February 4, 2016) John Goertz passed his Ph.D. proposal! Congratulations!

      (August 6, 2015) Stephen Restaino passed his Ph.D. proposal! Congratulations!

      (July 9, 2015) Adriel Sumathipala is selected as a regional finalist in the Google Science Fair.

      (May 21, 2015) Kunal Pandit successfully defended his Ph.D. dissertation! Congratulations!

      (March 31, 2015) Hieu Nguyen has been awarded the prestigious NSF Fellowship! Congratulations!

      (March 13, 2015) Imaly Nanayakkara (Bioengineering Ph.D. student) and Hieu Nguyen (Bioengineering Ph.D. student) have joined our group.

      (February 18, 2015) Our lab wins a MIPS award supported by the state of Maryland and Diagnostic anSERS.

      (June 5, 2014) Kristen Giles passes her Bioengineering Undergraduate Honors thesis defense.

      (May 14, 2014) Stephen Restaino wins the Distinguished Graduate Student Teaching Award from the University of Maryland Center for Teaching Excellence.

      (March 10, 2014) Kristen Giles wins Best Undergraduate Research Poster Award at the Mid-Atlantic Micro/Nano Alliance annual symposium.

      Giles Award

      (January 1, 2014) John Goertz, the 2013 winner of the Fischell Fellowship, has joined the group.

      Eric Hoppmann successfully defended his Ph.D. dissertation. Congratulations!

      Soroush Yazdi successfully defended his Ph.D. dissertation. Congratulations!

      Veemoon Yu was awarded the Fischell BIOE Outstanding Graduate Researcher for 2012-2013.

      Kristen Giles has been accepted into the BIOE Honors Program.

      Veemoon Yu successfully defended his Ph.D. dissertation. Congratulations!

      Hoppmann wins GRID competition with presentation on paper-SERS detection of PCR products.

      Virgile, Diagnostic anSERS, take third at the national Cupid's Cup Competition.

      Our lab wins a MIPS award, supported by the state of Maryland and Diagnostic anSERS.

      Yu's paper on inkjet-printed paper SERS dipsticks, swabs, and lateral flow concentration is selected for Analyst outside front cover.

      Analyst front cover

      Katayoon Saadin successfully defended her Ph.D. dissertation. Congratulations! She is the first graduate from our research group.

      Hoppmann, Virgile reach finals of MTECH's $75K Business Plan Competition.

      Our group wins a collaboration award from the FDA Center of Excellence in Regulatory Science and Innovation.

      Our paper-based SERS devices were featured by SPIE Newsroom.

      Our group wins a Blue Ocean Grant from Ocean Optics.

      Sean Virgile, the 2010 winner of the Fischell Fellowship, has joined the group.

      C&EN reports on Yu's ink-jet-printed SERS array.

      Yu publishes first ever ink-jet-printed SERS microdevice.

      SERS on paper image

      Available Positions

      Post-Doctoral Associates

      The Amplified Molecular Sensors Lab at the University of Maryland currently has an opening for a post-doc. The selected candidate's primary project would involve the rapid detection of antimicrobial resistance using novel materials and concepts in a paper/membrane platform. The selected candidate would also be encouraged to develop her/his own research ideas as side projects in order to generate potential future projects for the candidate and the group. Current areas of interest include:

      Technologies:

    • Paper-based diagnostic tools
    • Isothermal amplification
    • Novel uses of materials in sensing systems
    • Inkjet-printed surface-enhanced Raman sensors
    • Applications:

    • Culture-independent screening tools for antimicrobial resistance
    • Exosome and miRNA/mRNA detection
    • Infectious disease diagnosis
    • The selected candidate will be strongly encouraged to pursue career-enhancing fellowships. The selected candidate will also engage in proposal writing on behalf of the research group; strong writing capabilities are a must.

      Interested candidates should send a cover letter and CV to Prof. White.

      Graduate Students

      In the Fischell Department of Bioengineering, graduate students do not select research groups until the end of their first year. Therefore, if you are interested in joining our group, please first apply for admission to the department.

      Undergraduate Students

      Currently we do not have any undergraduate research positions available.

      Publications

      Peer-Reviewed Publications

      1. Miceala L. Everitt, David Boegner, Konstantin Birukov, and Ian M. White, Sample-to-Answer Diagnostic System for the Detection of Circulating Histones in Whole Blood, ACS Sensors, in press, 2021. DOI:10.1021/acssensors.1c00886.

      2. Miceala L. Everitt, Alana Tillery, Martha G. David, Nikita Singh, Aviva Borison, and Ian M. White, A critical review of point-of-care diagnostic technologies to combat viral pandemics, Analytica Chimica Acta, 1146, 184-189, 2020. DOI:10.1016/j.aca.2020.10.009.

      3. Shannon H. Hilton, Connor Hall, Hieu T. Nguyen, Micaela L. Everitt, Philip DeShong, and Ian M. White, Phenotypically distinguishing ESBL-producing pathogens using paper-based surface enhanced Raman sensors, Analytica Chimica Acta, 1127, 207-216, 2020. DOI:10.1016/j.aca.2020.06.068.

      4. Alessandra C. Zimmermann, Ian M. White, and Jason D. Kahn, Nucleic acid-cleaving catalytic DNA for sensing and therapeutics, Talanta, 211, 120709, 2020. DOI:10.1016/j.talanta.2019.120709

      5. Hieu T. Nguyen, Shweta Ganapati, David Watts, Imaly A. Nanayakkara, Philip DeShong, Ian M. White, A new trimodal phenotypic reporter of extended-spectrum beta-lactamase activity, ACS Infectious Disease, 5,1731-1737, 2019. DOI:10.1021/acsinfecdis.9b00138.

      6. Imaly A. Nanayakkara and Ian M. White, Demonstration of a quantitative triplex LAMP assay with an improved probe-based readout for the detection of MRSA, Analyst, 144, 3878 - 3885, 2019. DOI:10.1039/C9AN00671K.

      7. John P. Goertz, Kerry DeMella, Benjamin Thompson, Ian M. White, and Srinivasa Raghavan, Responsive capsules that enable hermetic encapsulation of contents and their thermally triggered burst-release, Materials Horizons, 1238-1243, 2019. DOI:10.1039/c9mh00309f.

      8. Stephen M. Restaino and Ian M. White, A critical review of flexible and porous SERS sensors for analytical chemistry at the point-of-sample, Analytica Chimica Acta, 1060, 17-29, 2019, DOI:10.1016/j.aca.2018.11.057

      9. John P. Goertz, Kenya Colvin, Andrew Lippe, John Daristotle, Peter Kofinas, and Ian M. White, Multi-Stage Chemical Heating for Instrument-Free Biosensing, ACS Applied Materials and Interfaces, 10, 33043–33048, 2018. DOI:10.1021/acsami.8b11611

      10. John P. Goertz and Ian M. White, Phase-change partitions for thermal automation of multi-step reactions, Analytical Chemistry, 90, 3708–3713, 2018. DOI:10.1021/acs.analchem.7b05400.

      11. Stephen M. Restaino and Ian M. White, Real-time multiplexed PCR using surface enhanced Raman spectroscopy in a thermoplastic chip, Lab on a Chip, 18, 832-839, 2018. DOI:10.1039/C7LC01227F.

      12. John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Nested Photochemical and Biochemical Positive Feedback, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.

      13. Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017. DOI:10.1021/acs.analchem.7b00274.

      14. Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

      15. Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

      16. Kunal R. Pandit, Paul E. Rueger, Richard V. Calabrese, Srinivasa R. Raghavan, and Ian M. White, Assessment of surfactants for efficient droplet PCR in mineral oil using the pendant drop technique, Journal of Colloids and Surfaces B: Biointerfaces, 126, 489-495, 2015. DOI:10.1016/j.colsurfb.2015.01.001

      17. Jeffrey M. Burke, Kunal Pandit, John P. Goertz, and Ian M. White, Fabrication of rigid microstructures with thiol-ene-based soft lithography for continuous-flow cell lysis, Biomicrofluidics, 8, 056503, 2014. DOI:10.1063/1.4897135.

      18. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

      19. Jeffrey M. Burke, Rebecca E. Zubajlo, Elisabeth Smela, and Ian M. White, High-throughput particle separation and concentration using spiral inertial filtration, Biomicrofluidics, 8, 024105 2014. DOI:10.1063/1.4870399.

      20. Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

      21. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

      22. Soroush H. Yazdi, Kristen L. Giles, and Ian M. White, Multiplexed detection of DNA sequences using a competitive displacement assay in an microfluidic SERRS-based device, Analytical Chemistry, 85, 10605-10611, 2013. DOI:10.1021/ac402744z.

      23. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

      24. Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

      25. Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, 15, 645-655, 2013. DOI:10.1007/s10544-013-9755-y.

      26. Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

      27. Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

      28. Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

      29. Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.

      30. Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.

      31. Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2

      32. Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

      33. Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)

      34. Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.

      35. I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.

      36. Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

      37. Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.

      Technical Conferences

      • John P. Goertz and Ian M. White, Covalently Modified Catalytic DNA for Sensitive Analyte Detection via PARCR, Mid-Atlantic DNA Nanotechnology Symposium, 2017, Gaithersburg, MD.

      • Alessandra Zimmermann, Jason Kahn, and Ian M. White, Isothermal DNA Detection Utilizing Bicyclic Amplification of Padlock Probes Mid-Atlantic DNA Nanotechnology Symposium, 2017, Gaithersburg, MD. (poster presentation)

      • John P. Goertz and Ian M. White, Phase-changing partitions for simple automation of multi-step reactions in a single-tube format, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Savannah, Georgia, October 2017.

      • Imaly A. Nanayakkara and Ian M. White, Characterization of Membrane Substrates to Enable DNA Capture and Direct Amplification for Paper-Based Nucleic Acid Amplification Tests, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Savannah, Georgia, October 2017. (poster presentation)

      • Ian M. White (presented by Stephen Restaino), Re-thinking surface enhance Raman spectroscopy (SERS) sensors with a systems perspective, Photonics West, 2017, San Francisco, CA. (Invited presentation)

      • Stephen M. Restaino and Ian M. White, Surface Enhanced Raman Spectroscopy (SERS) methods for endpoint and real-time quantification of miRNA assays, Photonics West, 2017, San Francisco, CA.

      • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Therapeutic drug monitoring in low resource settings with paper SERS, Photonics West, 2017, San Francisco, CA.

      • Adam G. Berger and Ian M. White, Therapeutic Drug Monitoring of Flucytosine in Serum using a SERS-active Membrane System, Photonics West, 2017, San Francisco, CA.

      • Adam G. Berger and Ian M. White, Vertical flow assay and paper SERS for therapeutic drug monitoring of flucytosine from undiluted serum, BMES, 2016, Minneapolis, MN.

      • Imaly A. Nanayakkara and Ian M. White, Simplifying nucleic acid amplification with cell lysis, DNA capture and direct PCR at the surface of chitosan microbeads, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, October 2016. (poster presentation)

      • Ian M. White, Sample processing and sensing, Optical Biosensors Incubator: Future of Optical Biosensors for Point-of-Care Applications, Washington, D.C., 2015. (Invited presentation)

      • Ian M. White, Inkjet-printed fluidic paper SERS devices for chemical and biological analytics, Advances in Optics for Biotechnology, Medicine, and Surgery XIV, Vail, CO, 2015. (Invited presentation)

      • Ian M. White, SERS-based chemical and biological analytics on inkjet-fabricated paper devices, AVS Mid-Atlantic, Gaithersburg, MD, 2015. (Invited presentation)

      • Stephen M. Restaino and Ian M. White, Inkjet-fabricated surface enhanced Raman spectroscopy (SERS) sensors on paper for biosensing, Photonics West, 2015, San Francisco, CA.

      • John P. Goertz and Ian M. White, Smartphone-enabled filterless fluorescence assay utilizing the pyrene excimer, Photonics West, 2015, San Francisco, CA.

      • Ian M. White, Wei W. Yu, Eric P. Hoppmann, Soroush H. Yazdi, SERS-based biological analytics on inkjet-fabricated paper devices, SciX 2014, Reno, NV (Invited presentation).

      • Ian M. White, Sample preparation for point-of-care bloodstream infection diagnostics, Next Generation Diagnostics Summit 2014, Washington D.C. (Invited presentation).

      • Ian M. White, Surface enhanced Raman spectroscopy sensing of chemical and biological molecules on low-cost microporous devices, Complex Fluids II, 2014, Durham, NC (Invited presentation).

      • Wei W. Yu, Eric P. Hoppmann, and Ian M. White, Inkjet-printed fluidic paper SERS devices for chemical and biological analytics, SciX 2013, Milwaukee, WI (Invited presentation).

      • Ian M. White, Fluidic paper SERS devices for chemical and biological analytics, 2nd European Optical Society Conference on Optofluidics, 2013, Munich, Germany (Invited presentation).

      • Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.

      • Wei W. Yu and Ian M. White, Paper SERS chromatography for detection of trace analytes in complex samples, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.

      • Eric P. Hoppmann and Ian M. White, A paper-based inkjet-fabricated substrate for SERS detection and differentiation of PCR products, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.

      • Wei W. Yu and Ian M. White, Inkjet-Fabricated SERS-Active Swab-Dipstick, OSA Optical Sensors, 2012, Monterey, CA.

      • Soroush H. Yazdi and Ian M. White, A Nanoporous Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Melamine, CLEO, 2012, San Jose, CA

      • Wei W. Yu and Ian M. White, Optofluidic SERS on Paper: A Lateral Flow Concentration Assay Using Inkjet Fabricated SERS-Active Substrates, CLEO, 2012, San Jose, CA

      • Ian M. White and Wei W. Yu, Optofluidic SERS on inkjet-fabricated paper-based substrates (Invited presentation), Photonics West, 2012, San Francisco, CA

      • Katayoon Saadin and Ian M. White, Mammosphere culture of cancer stem cells in a microfluidic device, Photonics West, 2012, San Francisco, CA

      • Soroush H. Yazdi and Ian M. White, 3D nanoporous optofluidic device for high sensitivity SERS detection, Photonics West, 2012, San Francisco, CA

      • Ian M. White and Katayoon Saadin, Studying the mechanisms of cancer metastasis in microsystems, Lab on a Chip World Congress, 2011, South San Francisco, CA

      • Ian M. White, Optofluidic biosensors, APC Workshop: Biomedical Optical Sensors - Differentiators for Winning Technologies, 2011, Toronto, ON.

      • Ian M. White, Ink-Jet-Printed Optofluidic SERS for Molecular Analysis (Invited presentation), OSA Optical Sensors, 2011, Toronto, ON.

      • Wei W. Yu and Ian M. White, Paper-based optofluidic SERS using ink-jet-printed substrates, Photonics West 2011, San Francisco, CA.

      • Katayoon Saadin and Ian M. White, A novel microfluidic device for on-chip enrichment of tumorigenic breast cancer cells via mammosphere culture, MRS Fall Meeting 2010, Boston, MA.

      • I-Jane Chen and Ian M. White, Sandwich Structure Electrochemical Assay for Single Stranded DNA Detection, IEEE Sensors 2010, Waikoloa, HI.

      • Kunqiang Jiang, Ian M. White, and Don L. DeVoe, Detection of trace explosives by SERS using 3-D nanochannel arrays, microTAS 2010, Groningen, The Netherlands

      • Jikun Liu, Ian M. White, and Don L. DeVoe, microTAS 2010, Groningen, The Netherlands

      • Jikun Liu, Don L. DeVoe, and Ian M. White, Microfluidic SERS Using a 3-Dimensional Porous Monolith as a SERS-Active Solid Phase in a Microchannel, CLEO 2010, San Jose, CA

      • I-Jane Chen and Ian M. White, Electrochemical Immunoassay for DNA Sensor, Pittcon 2010, Orlando, FL.

      • Eric Hoppmann and Ian M. White, Electrostatic Purification of Nucleic Acids for Micro Total Analysis Systems, Southern Biomedical Engineering Conference 2010, College Park, MD.

      • Farnoosh Farahi and Ian M. White, Integration of Capillary Ring Resonator Biosensor with PDMS Microfluidics for Label-free Biosensing, Southern Biomedical Engineering Conference 2010, College Park, MD.

      • Ian M. White, Optofluidic biosensing for the study of disease at the molecular level (Invited presentation), Photonics West 2010, San Francisco, CA.

      Sponsors