Wolfgang Losert

Dynamics of Living and Complex Systems

Dynamics of Living Systems: Our goal is to assess how the motion of individual cells and the collective dynamics of cell groups are affected by physical cues, in particular the topography of the microenvironment. Together with John Fourkas (Chemistry) my group discovered that cell migration can be guided by nanotopography via control of the dynamics of actin waves. Recent work has further demonstrated that unidirectional cell guidance is possible through asymmetric nanotopography alone without chemical cues. Funded by NIGMS, NSF, AFOSR.

Complex Dynamics: Granular systems are excellent models for fundamental questions about collective dynamics. We have developed a novel approach that allows to image in three dimensions both motion and rotations of all particles in a dense system of particles. Our goal is to understand how chaotic motions and rotations at the particle scale level can lead to strikingly robust collective behavior such as avalanches. Funded by NSF-DMR.

BRAIN Initiative: My group leads the Data Science Core, and co-leads the technology core of a BRAIN initiative Center grant entitled "Readout and control of spatiotemporal neuronal codes for behavior". We deploy new imaging technologies and data analysis techniques that will further our understanding of how large networks of neurons in the brain interact to process sensory information. (News) Work supported by a BRAIN Initiative Center grant from NIH-NINDS.

MURI: Understanding and Controlling the Coupled Electrical, Chemical, & Mechanical Excitable Networks of Living Systems: In this MURI, we take a comprehensive, multidisciplinary approach to elucidate the integration of biochemical, electrical and mechanical (BEM) signals in single cells and multicellular collectives. Our objective is to demonstrate how excitable network characteristics allow for novel cellular control strategies using controlled electric fields (EFs). This MURI will provide robust foundation of basic biophysical insights that will provide the cornerstones for new man-machine interface designs geared to physiology and human performance. Work supported by a MURI from AFOSR.

Contact

Dean's Office:Symons Hall, Room 2310, 301-405-2327

IPST Office:Atlantic Building, Room 4415, 301-405-4814

Coordinator: Mary Kearney

Research Office:Physical Sciences Complex, Room 1147,301-405-0629

Biodynamics Lab:Physical Sciences Complex, Room B0256

Optics Lab:Physical Sciences Complex, Room B0163

E-mail: wlosert @ umd.edu

Send Mail To:
Institute for Physical Science and Technology
4254 Stadium Dr Rm 4115
Univ. of Maryland, College Park, MD 20742

More Information

PDF of Current CV


Affiliations


Lab Outreach

The Losert Lab has participated in Maryland Day since 2001. To learn more about the demonstrations we have developed and the activities we host, check out our Maryland Day page.