Samuel (Sam) S. Cho
Jump to: [Professional Experience] - [Education] - [Awards] - [Teaching Experience] - [Publication List] - [Invited Talks] - [Poster Presentations]
Contact Information
University of Maryland
Institute for Physical Science and Technology
Department of Chemistry and Biochemistry
Building 085
College Park, MD 20742
Office: (301) 405-4786
 samscho@umd.edu
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Professional Experience
University of Maryland
Post-Doctoral Research Fellow
Advisor: Devarajan (Dave) Thirumalai
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2007-Present
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University of California, San Diego
Doctoral Research Fellow
Advisor: Peter G. Wolynes
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2001-2007
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University of Maryland, Baltimore,
School of Pharmacy
Undergraduate Research Fellow
Advisor: Alexander D. Mackerell, Jr.
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2000-2001
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Education
University of California, San Diego
- Ph.D., Physical Chemistry (2007)
- M.S., Chemistry (2003)
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2001-2007 |
University of Maryland, Baltimore County
- B.S., Molecular Biology and Biochemistry (2001)
- B.S., Computer Science (2001)
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1996-2001 |
Awards and Honors
| NIH (NRSA) Post-Doctoral Research Fellowship (UMd) |
2007-2010 |
| Molecular Biophysics Training Program (UCSD) |
2003-2005 |
| Teaching Assistant Excellence Award (UCSD) |
2003 |
| President's Scholar Award (UMBC) |
1996-2000 |
Teaching Experience
University of California, San Diego
Graduate Teaching Assistant
- Chemistry 126: Physical Chemistry (Fall 2002)
- Chemistry 6CL: Introduction to Analytical Chemistry (Spring
2002)
- Chemistry 6B: General Chemistry (Winter 2002)
- Chemistry 6BL: Introductory Inorganic Chemistry Lab (Fall
2001)
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2001-2002 |
University of Maryland, Baltimore County
Undergraduate Teaching Assistant
- Computer Science 201: Introduction to Computer Science
(Fall 2000 and Spring 2001)
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2000-2001 |
Publication List
| 1. Izaguirre G, Pietruszko R, Cho SS, MacKerell
AD. Human aldehyde dehydrogenase catalytic activity and structural
interactions with coenzyme analogs. J. Biomol. Struct. Dyn.
2001, 19(3):429-447.
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| 2. Pan YP, Huang N, Cho SS, MacKerell AD. Consideration
of molecular weight during compound selection in virtual target-based
database screening. J. Chem. Inf. Comp. Sci. 2003, 43
(1): 267-272. |
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| 3. Wymore T, Hempel J, Cho SS, MacKerell AD,
Nicholas HB, Deerfield DW. Molecular recognition of aldehydes
by aldehyde dehydrogenase and mechanism of nucleophile activation. Proteins 2004, 57 (4): 758-771. |
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| 4. Yang SC, Cho SS, Levy Y, Cheung MS, Levine
H, Wolynes PG, Onuchic JN. Domain swapping is a consequence of
minimal frustration. Proc. Natl. Acad. Sci., USA. 2004,
101 (38): 13786-13791. |
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| 5. Levy Y, Cho SS, Onuchic JN, Wolynes PG. A
survey of flexible protein binding mechanisms and their transition
states using native topology based energy landscapes. J. Mol.
Biol. 2005, 346 (4): 1121-1145. |
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| 6. Levy Y, Cho SS, Shen T, Onuchic JN, Wolynes
PG. Symmetry and frustration in protein energy landscapes: A near
degeneracy resolves the Rop dimer-folding mystery. Proc. Natl.
Acad. Sci., USA. 2005, 102 (7):2373-2378. |
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7. Cho SS, Levy Y, Onuchic JN, Wolynes PG. Overcoming
residual frustration in domain-swapping: The roles of disulfide
bonds in dimerization and aggregation. Phys. Biol. 2005,
2: S44-S55.
Institute of Physics (IOP) Interview |
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| 8. Ferreiro DU, Cho SS, Komives EA, Wolynes PG.
The energy landscape of modular repeat proteins: Topology determines
folding mechanism in the ankyrin family. J. Mol. Biol. 2005, 354 (4): 679-692. |
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| 9. Cho SS, Levy Y, Wolynes PG. P versus Q: Structural
reaction coordinates capture protein folding on smooth landscapes. Proc. Natl. Acad. Sci., USA. 2006, 103 (3): 586-591. |
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| 10. Ferreiro DU, Cervantes CF, Truhlar SME, Cho SS,
Wolynes PG, Komives EA. Stabilizing IkBa by 'consensus' design. J. Mol. Biol. 2007, 365 (4): 1201-1216. |
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| 11. Cho SS, Weinkam P, Wolynes PG. Origins of barriers and
barrierless folding of BBL. Proc. Natl. Acad. Sci., USA. 2008, 105 (1):118-123. |
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| 12. Pincus DL, Cho SS, Hyeon C, Thirumalai D, "Minimal models
for protein and RNA: From folding to function", Chapter 6 in Progress in Molecular Biology and Translational Science edited by
P. Michael Conn (2008) Academic Press, Vol. 84. |
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| 13. Lenz P, Cho SS, Wolynes PG. Analysis of single molecule
folding studies with replica correlation functions. Chem. Phys. Lett. 2009, 471 (4-6):310-314. |
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| 14. Cho SS, Levy Y, Wolynes PG. Quantitative criteria for
native energetic heterogeneity influences in the prediction of protein folding
kinetics. Proc. Natl. Acad. Sci., USA. 2009, 106 (2):434-439. |
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| 15. Cho SS, Pincus DL, Thirumalai D. Assembly mechanisms of RNA pseudoknots are determined by the stabilities of the constituent secondary structures. Proc. Natl. Acad. Sci., USA. 2009, 106 (41):17349-17354. |
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| 16. Cho SS, Straub JE, Thirumalai D. Molecular Mechanism for the Entropic Stabilization of Proteins by TMAO. J. Amer. Chem. Soc. 2009 (in submission). |
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Invited Talks
| 1. Mesilla Chemistry Workshop: Multi-Scale Modeling of Biological Molecules (Mesilla, NM), "Ordered and/or parallel RNA folding mechanisms". |
2009 |
| 2. American Physical Society Meeting (Pittsburgh, PA), "Stabilities of constituent hairpins determine whether RNA folds via ordered and/or parallel mechanisms". |
2009 |
Poster Presentations
| 1. American Chemical Society Meeting (Washington, DC), "MD simulations of NAD(+) coenzyme analogs in the active site of ALDH reveal the impact of chemical substitutions on enzymatic activity". |
2000 |
| 2. Gordon Research Conference: Protein Folding Dynamics (Ventura, CA), "The principle of minimal frustration in domain-swapping". |
2004 |
| 3. Biophysical Society Meeting (Baltimore, MD), "Application of the principle of minimal frustration to structure prediction of domain-swapping proteins". |
2004 |
| 4. Protein Society Meeting (San Diego, CA), "Minding your p's and q's: Structural reaction coordinates capture protein folding on smooth landscapes". |
2006 |
| 5. Protein Society Meeting (San Diego, CA), "Two state or not two state: Origins of barriers and barrierless folding of BBL". |
2008 |
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