Maria I. Klapa 

Assistant Professor
Department of Chemical Engineering
University of Maryland
College Park, MD 20742-2111

OFFICE 1227A Chemical & Nuclear Eng. Bldg. (090)
TELEPHONE (301) 405-1320
FAX (301) 405-0523
E-MAIL mklapa@eng.umd.edu


EDUCATION / TRAINING 

Postdoctoral Fellow, Functional Genomics, The Institute for Genomics Research (TIGR), 2002  

Postdoctoral Research Associate, Chemical Engineering, Massachusetts Institute of Technology (MIT), 2001 

Ph.D., Chemical Engineering, Massachusetts Institute of Technology (MIT), 2001 

Diploma, Chemical Engineering, National Technical University of Athens (N.T.U.A.), Greece, 1995


RESEARCH INTERESTS 

 Metabolic Engineering with emphasis in Metabolic Flux Analysis & Metabolic Profiling

 Functional Genomics

 Mathematical Modeling of Biological Networks

 Quantitative Systems Biology

 Publications                   Presentations/Posters


TEACHING 

 ENCH468H/ ENCH 762:  Advances in Metabolic Engineering & Quantitative Systems Biology


CURRENT RESEARCH  (this part is under major construction!)

  • Quantitative Systems Biology of the plant Arabidopsis thaliana

Arabidopsis thaliana is the "drosophila" of plants. Having a relatively small genome of 5 chromosomes and short growth cycle, it provides a good model system for the analysis of plant physiology. In collaboration with the group of Dr. John Quackenbush at The Institute for Genomic Research (TIGR), plants are grown under various environmental conditions and their physiological state is monitored at the genomic level using full-genome DNA microarrays, developed at TIGR, and at the metabolic level, using Gas Chromatography-ion-trap Mass Spectrometry, at UMD. Integration of the gene expression and metabolic profiles under a variety of perturbations can provide insight about the function of unknown genes, the relationship between gene and metabolic regulation and even the reconstruction of the gene regulation network.

 


last updated: January 22, 2003