Maria I. Klapa Assistant Professor
Department of Chemical Engineering
University of Maryland
College Park, MD 20742-2111OFFICE 1227A Chemical & Nuclear Eng. Bldg. (090)
TELEPHONE (301) 405-1320
FAX (301) 405-0523
E-MAIL mklapa@eng.umd.edu
EDUCATION / TRAINING
Postdoctoral Fellow, Functional Genomics, The Institute for Genomics Research (TIGR), 2002
Postdoctoral Research Associate, Chemical Engineering, Massachusetts Institute of Technology (MIT), 2001
Ph.D., Chemical Engineering, Massachusetts Institute of Technology (MIT), 2001
Diploma, Chemical Engineering, National Technical University of Athens (N.T.U.A.), Greece, 1995
RESEARCH INTERESTS
Metabolic Engineering with emphasis in Metabolic Flux Analysis & Metabolic Profiling
Functional Genomics
Mathematical Modeling of Biological Networks
Quantitative Systems Biology
Publications Presentations/Posters
TEACHING
ENCH468H/ ENCH 762: Advances in Metabolic Engineering & Quantitative Systems Biology
CURRENT RESEARCH (this part is under major construction!)
Quantitative Systems Biology of the plant Arabidopsis thaliana
Arabidopsis thaliana is the "drosophila" of plants. Having a relatively small genome of 5 chromosomes and short growth cycle, it provides a good model system for the analysis of plant physiology. In collaboration with the group of Dr. John Quackenbush at The Institute for Genomic Research (TIGR), plants are grown under various environmental conditions and their physiological state is monitored at the genomic level using full-genome DNA microarrays, developed at TIGR, and at the metabolic level, using Gas Chromatography-ion-trap Mass Spectrometry, at UMD. Integration of the gene expression and metabolic profiles under a variety of perturbations can provide insight about the function of unknown genes, the relationship between gene and metabolic regulation and even the reconstruction of the gene regulation network.
last updated: January 22, 2003
