Biochemistry: BCHM 461

Fall 2017

Course meets in Chem 1402, MW 4:00-5:15 pm
Professor: David Fushman
Office: Room 1121 Biomolecular Sciences Bldg (#296)
Office Hours: Tuesday 12:30 - 2:30 pm
E-mail: fushman@umd.edu

Syllabus

Textbooks

Required:
Lehninger Principles of Biochemistry, 6th edition by Nelson and Cox
Recommended:
The Absolute, Ultimate Guide to Lehninger Principles of Biochemistry, 6th edition by Osgood and Ocorr ;
Biochemistryr by Voet and Voet;
 
Assignments:
Reading and problem assignments are from Lehninger Principles of Biochemistry
Date Reading Problems Q&A
12/19 FINAL EXAM: 1:30-3:30pm; Rm 1402    
12/11 Last class. In addition to some lecture material we will have a review session -- bring your questions Statistics of Exam #2 (below) now include the distribution of the current scores.  Answers to Quiz #5 problems are here. 
12/06 Ch.7: pp. 243-262; Table 7-2. Ch.7, Problems: 1-12,15-19.  
12/04 Ch.6, pp. 199-200, 214-218, 226-231   Answers to Exam #2 problems and the statistics of the current total scores are posted below.
11/29 Ch.6, pp. 207-213 Ch.6, Problems 16,17,19,20,22. Your Quiz #5 is here. It's due on Monday Dec.4th.  
11/27 Ch.6, pp. 206-207 Ch.6, Problems 16,19  
11/20 Midterm Exam #2    
11/15 Ch.6: pp 200-203 Ch.6: Problem 8.  
11/13 Ch.6: pp 189-198 Ch.6: Problems 1-4,7. Solutions to the sample problems from previous exams are here. One of the equations in Problem 1c was messed up when converting to PDF -- now corrected. Review session: Wed Nov 15, right after the lecture. Bring your questions. 
11/08 Ch.5: pp 166-174 Ch.5: Problems 2,6,7. Your Quiz #4 (due on Monday Nov 13) is here. Sample problems from previous exams can be found here.  Answers to Quiz #3 questions are here. 
11/06 Ch.5: pp 158-166 Ch.5: Problems 3,6,9  
11/01 Ch.5: pp 157-161 + Lecture notes Ch.5: Problems 1,4,5,16  
10/30 Lecture notes on NMR. Watch youtube videos listed on slide #9. Your Quiz #3 is here . It is due on Monday November 6th.  
10/25 Lecture notes on small-angle scattering and cryo-EM.    Answers to Exam #1 problems and scores statistics are posted below.
10/23 Ch.4, Box 4-5 lecture notes on X-ray crystallography    
10/18 Ch.4: pp 125, Box 4-5 + lecture slides    
10/16 Ch.4: pp 143-151 Ch.4: problem #14.  
10/11 Midterm Exam #1    
10/09 Ch.4 pp. 125-133; 137-143. Review session after class, Rm 1402. Bring your questions.    
10/04 Ch.4 pp. 123-125; 125-133. Preparation for the midterm exam. Solutions to sample problems from previous exams are here. Open this file only after you solved or tried to solve the problems yourself!   Solutions to Quiz #2 problems are here
10/02 Ch.4, pp. 115-125. Ch.4, Problems: 1-4,10,13. Sample problems from previous exams can be found here. Solutions to these problems will be posted here later. Solution to the old pH problem set are here. Soluitions to Lecture 9 homework problems related to determining amino acid sequence are here
09/27 Ch.3, pp. 96-109 Ch.3. Problems 18-20,23. Homework problems in the lecture slides (also available here.).  
09/25 Ch.3, pp. 89-96 Ch.3, Problems 16,17,22  
09/20 Ch.3, pp.85-89 Ch.3, Problems: 11; Compute the average mol.weight of an amino acid in a protein. Here is your Quiz #2. It is due on Wednesday Sept 27. The lecture slides (on Canvas) now contain an illustration of how we analyzed charged states of a peptide in class as well as computer-generated plots of the average charge vs. pH. Answers to Quiz #1 questions are here.
09/18 Ch.3, pp. 75-85 Ch.3, Problems 1-4,7,11-14.  
09/13 Ch.2, pp. 58-70 (finish reading) Ch.2, Problems: 18-22,24-30; practice problems 6-8 from handout problems set. A detailed derivation of the equation for the pH problem considered in class is here.
09/11 Ch.2, pp. 58-70 Ch.2, Problems: 2,3,5-9,11-15. Handout problems (+answers) set can be downloaded from here. Do practice problems 1-5. .
09/06 Ch. 2, pp: 45-58 Ch.2, p.71, Pr. 1. Your first Quiz (due on Sept 11, 2017) is here.  
08/30 Ch.1: pp.20-27; Ch.13: pp.505-511 Ch.13: pp.538-539, Problems #2-5. Also Problems I-III and Questions in Lecture_2 notes (ELMS) -- these problems can be found here.  
08/28 Ch.1, pp. 1-20 Ch.1: Problems: 3,7,9; Figure 1-16: refresh your memory of the chemical properties of the functional groups shown in that figure.  
Exam # 1: Exam # 2: Final Exam:
Statistics Statistics Statistics
Solutions Solutions Solutions
     

Link to UMD CANVAS website

Link to Fushman Lab homepage