Physical BioChemistry: BCHM 485

Spring 2018

Course meets in Chem 2201, TuTh 9:30 am
Professor: David Fushman
Office: Room 1121 Biomolecular Sciences Bldg (#296)
Office Hours: Tuesday, 12:30 - 2:30 pm



Quantum Chemistry & Spectroscopy by Thomas Engel
Thermodynamics, Statistical Thermodynamics, and Kinetics by Thomas Engel & Philip Reid
(The Molecular Thermodynamics textbook by McQuarrie & Simon that you might have from the CHEM481 course could be sufficient.)
Physical Chemistry by Peter Atkins and Julio de Paula, Vol.2 Quantum Chemistry, Spectroscopy, and Statistical Thermodynamics;
Physical Chemistry with Applications to the Life Sciences by David Eisenberg and Donald Crothers;
Principles of Physical Biochemistry by van Holde, Johnson & Ho;
Molecular Driving Forces by Dill & Bromberg;
Biophysical Chemistry by Cantor & Schimmel.
Reading and problems are either from Quantum Chemistry & Spectroscopy [QCS] or from Thermodynamics, Statistical Thermodynamics, and Kinetics [TSK]
Date Reading Problems Q&A
02/22 Ch.5: 5.3; Ch 7: 7.1,7.3 Ch.5: Pr: 5.4,5.5; Ch.7: Ex.Pr.: 7.1, 7.2; Qs:7.1,7.6,7.8; Pr: 7.8,7.14,7.16,7.18  
02/20 Ch.6:6.1,6.3,6.4, Ch.6: Example Prs: 6.3, 6.4, Qs: 6.5-8,6.14; Pr: 6.3,6.6,6.7 ,6.9,6.11,6.23. Prove the genearal relationships for the commutators which I gave you in class. Specifically, evaluate the commutator [A,BC].  
02/15 Ch.4: 4.3; Ch.5: 5.1-5.2, 5.6-5.8 Ch.4: Pr: 4.17-18; Ch.5: Qs: 5.6; Pr: 5.7. Harry Potter and Platform 9 3/4: was it a quantum effect or just magic? Estimate the penetration depth assuming a 2m high gravitational barrier and a particle (Harry Potter) of mass 50 kg running at 2 m/sec toward the barrier.  
02/13 Ch. 2.1; Ch.4: 4.2, 4.4 Ch.4: Ex.Pr.4.1-4.3; Pr: 4.12,4.16. Estimate your wavelength when you move with 10 m/s velocity. Compute the wavelength for an oxygen molecule at room temperature.  
02/08 Ch.4: 4.2 Ch.4: Qs: 4.1-2,4.6,4.9-11,4.14-15,4.18-20; Pr: 4.9,4.10,4.29. Think of the Happy Potter and the Basilisk problem. Your graded Homework #1 (due Feb 15, 2018) is here. Some useful trigonometric equations and and identities are here.  
02/06 Ch.4: 4.1 Ch.4: Qs: 4.3-5,4.11; Pr: 4.4-4.6,4.13.  
02/01 Ch.3: 3.1-3.5 (3.6) Ch.3: Qs: 3.9-3.10; Pr: 3.12,3.16 (3.5,3.6). Q#1: Schroedinger's cat was found alive in 64% experiments and dead in 36%. Reconstruct the wavefunction of the cat. Q#2: How could you tell from the outcomes of your experiments if the QM system is in a pure state or in a superposition state?  
01/30 Ch.2: 2.3,2.6,2.7; Ch.3: 3.1-3.3. Ch.2: Ex.Pr. 2.3,2.4; Pr: 2.12, 2.14; Ch.3: Qs:3.2-3.9; Pr: 3.1,3.2,3.8,3.9  
01/25 QCS: Ch.1 & Ch.2: 2.2-2.3 Ch.1: Do Example problem: 1.3 from Ch.1: determine the radius of the lowest-energy orbit of electron in Bohr;s planetary model of the hydrogen atom. Using Wien's displacement law, λmax*T=1.44/5 cm*K, do the following calculations: (1) estimate λmax for your body radiation, and (2) assuming that λmax ~ 550 nm for the Sun's radiation, estimate the temperature of the Sun's surface. It's not too late to prepare yourself for the course. The relevant information can be found here.   
Exam # 1: Exam # 2: Final Exam:
Statistics Statistics Statistics
Solutions Solutions Solutions

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