Material Safety Data Sheet
Methanol

ACC# 14280
Section 1 - Chemical Product and Company Identification

MSDS Name: Methanol
Catalog Numbers: S75959, S75965, S75965A, S75965HPLC, S75965SPEC, A408-1, A408-4, A408SK-4, A411-20, A411-4, A412-1, A412-20, A412-200, A412-200LC, A412-4, A412-4LC, A412-500, A412-500LC, A412CU1300, A412FB115, A412FB19, A412FB200, A412FB50, A412J500, A412P-4, A412P-4LC, A412POP19, A412POP200, A412POP50, A412POPB19, A412POPB200, A412POPB50, A412RB115, A412RB19, A412RB200, A412RB50, A412RS115, A412RS200, A412RS28, A412RS50, A412SK-4, A412SS-115, A412SS-19, A412SS-200, A413-20, A413-200, A413-4, A413-500, A433F-1GAL, A433P-4, A433P1GAL, A433S-20, A433S-200, A433S-4, A434-20, A450-4, A452-1, A452-4, A452-4LC, A452J1, A452NB219, A452POP19, A452POP200, A452POP28, A452POP50, A452POPN19, A452RS-115, A452RS-19, A452RS-200, A452RS-28, A452RS-50, A452SK-1, A452SK-4, A452SS-115, A452SS-19, A452SS-200, A452SS-50, A453-1, A453-1LC, A453-500, A453J1, A454-1, A454-1LC, A454-4, A454-4LC, A454POP19, A454POP200, A454POP50, A454RS-115, A454RS-19, A454RS-200, A454RS-28, A454RS-50, A454SS-19, A454SS-28, A454SS-50, A455-1, A455POP19, A455POP200, A455POP50, A455SS19, A455SS200, A455SS50, A457-4, A935-4, A935FB200, A935POPB200, A935RB200, A936-1, A936-4, A947-4, A947-4LC, A947POP19, A947POP200, A947POP50, A947RS-115, A947RS-200, A947RS-28, A947SS-115, A947SS-19, A947SS-200, A947SS-28, A947SS-50, BP1105-1, BP1105-4, BP1105POP19, BP1105POP20, BP1105POP50, BP1105RS19, BP1105SS19, BP1105SS28, BP1105SS50, BP2618100, HC400 1GAL, NC9633361, NC9766429, NC9780216, NC9905242, NC9941388, NC9942270, NC9964975, NC9979250, SC95-1, SW2-1, TIA9474, TIA947P200L
Synonyms:
Carbinol; Methyl alcohol; Methyl hydroxide; Monohydroxymethane; Wood alcohol; Wood naptha; Wood spirits; Columbian spirits; Methanol.
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
201-796-7100
Emergency Number:
201-796-7100
For CHEMTREC assistance, call:
800-424-9300
For International CHEMTREC assistance, call:
703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
67-56-1 Methanol >99.0 200-659-6

Hazard Symbols:
T F
Risk Phrases:
11 23/24/25 39/23/24/25

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: clear, colorless liquid. Flash Point: 11 deg C. Poison! Cannot be made non-poisonous. Causes eye and skin irritation. Danger! Flammable liquid and vapor. May be fatal or cause blindness if swallowed. May cause central nervous system depression. Causes respiratory tract irritation. Harmful if swallowed, inhaled, or absorbed through the skin. Vapor harmful.
Target Organs: Eyes, nervous system, optic nerve.


Potential Health Effects
Eye: Methanol is a mild to moderate eye irritant. Inhalation, ingestion or skin absorption of methanol can cause significant disturbances in vision, including blindness.
Skin: Causes moderate skin irritation. Harmful if absorbed through the skin. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. Methanol can be absorbed through the skin, producing systemic effects that include visual disturbances.
Ingestion: Harmful if swallowed. May be fatal or cause blindness if swallowed. Aspiration hazard. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation: Methanol is toxic and can very readily form extremely high vapor concentrations at room temperature. Inhalation is the most common route of occupational exposure. At first, methanol causes CNS depression with nausea, headache, vomiting, dizziness and incoordination. A time period with no obvious symptoms follows (typically 8-24 hrs). This latent period is followed by metabolic acidosis and severe visual effects which may include reduced reactivity and/or increased sensitivity to light, blurred, double and/or snowy vision, and blindness. Depending on the severity of exposure and the promptness of treatment, survivors may recover completely or may have permanent blindness, vision disturbances and/or nervous system effects.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Chronic exposure may cause effects similar to those of acute exposure. Methanol is only very slowly eliminated from the body. Because of this slow elimination, methanol should be regarded as a cumulative poison. Though a single exposure may cause no effect, daily exposures may result in the accumulation of a harmful amount. Methanol has produced fetotoxicity in rats and teratogenicity in mice exposed by inhalation to high concentrations that did not produce significant maternal toxicity.

Section 4 - First Aid Measures


Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: Potential for aspiration if swallowed. Get medical aid immediately. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Effects may be delayed.
Antidote: Ethanol may inhibit methanol metabolism.

Section 5 - Fire Fighting Measures


General Information: Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water.
Flash Point: 11 deg C ( 51.80 deg F)
Autoignition Temperature: 464 deg C ( 867.20 deg F)
Explosion Limits, Lower:6.0 vol %
Upper: 36.00 vol %
NFPA Rating: (estimated) Health: 1; Flammability: 3; Instability: 0

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to disperse the gas/vapor. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame. Avoid use in confined spaces. Avoid breathing vapor or mist.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Keep containers tightly closed.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Methanol 200 ppm TWA; 250 ppm STEL; skin - potential for cutaneous absorption 200 ppm TWA; 260 mg/m3 TWA 6000 ppm IDLH 200 ppm TWA; 260 mg/m3 TWA

OSHA Vacated PELs: Methanol: 200 ppm TWA; 260 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: clear, colorless
Odor: alcohol-like - weak odor
pH: Not available.
Vapor Pressure: 127 mm Hg @ 25 deg C
Vapor Density: 1.11 (Air=1)
Evaporation Rate:5.2 (Ether=1)
Viscosity: 0.55 cP 20 deg C
Boiling Point: 64.7 deg C @ 760 mm Hg
Freezing/Melting Point:-98 deg C
Decomposition Temperature:Not available.
Solubility: miscible
Specific Gravity/Density:.7910 g/cm3 @ 20C
Molecular Formula:CH4O
Molecular Weight:32.04

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: High temperatures, ignition sources, confined spaces.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, powdered aluminum, powdered magnesium.
Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, formaldehyde.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information


RTECS#:
CAS# 67-56-1: PC1400000
LD50/LC50:
CAS# 67-56-1:
Draize test, rabbit, eye: 40 mg Moderate;
Draize test, rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, skin: 20 mg/24H Moderate;
Inhalation, rabbit: LC50 = 81000 mg/m3/14H;
Inhalation, rat: LC50 = 64000 ppm/4H;
Oral, mouse: LD50 = 7300 mg/kg;
Oral, rabbit: LD50 = 14200 mg/kg;
Oral, rat: LD50 = 5600 mg/kg;
Skin, rabbit: LD50 = 15800 mg/kg;
Carcinogenicity:
CAS# 67-56-1: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No data available.
Teratogenicity: There is no human information available. Methanol is considered to be a potential developmental hazard based on animal data. In animal experiments, methanol has caused fetotoxic or teratogenic effects without maternal toxicity.
Reproductive Effects: See actual entry in RTECS for complete information.
Neurotoxicity: ACGIH cites neuropathy, vision and CNS under TLV basis.
Mutagenicity: See actual entry in RTECS for complete information.
Other Studies: No data available.

Section 12 - Ecological Information


Ecotoxicity: Fish: Fathead Minnow: 29.4 g/L; 96 Hr; LC50 (unspecified) Goldfish: 250 ppm; 11 Hr; resulted in death Rainbow trout: 8000 mg/L; 48 Hr; LC50 (unspecified) Rainbow trout: LC50 = 13-68 mg/L; 96 Hr.; 12 degrees C Fathead Minnow: LC50 = 29400 mg/L; 96 Hr.; 25 degrees C, pH 7.63 Rainbow trout: LC50 = 8000 mg/L; 48 Hr.; Unspecified ria: Phytobacterium phosphoreum: EC50 = 51,000-320,000 mg/L; 30 minutes; Microtox test No data available.
Environmental: Dangerous to aquatic life in high concentrations. Aquatic toxicity rating: TLm 96>1000 ppm. May be dangerous if it enters water intakes. Methyl alcohol is expected to biodegrade in soil and water very rapidly. This product will show high soil mobility and will be degraded from the ambient atmosphere by the reaction with photochemically produced hyroxyl radicals with an estimated half-life of 17.8 days. Bioconcentration factor for fish (golden ide) < 10. Based on a log Kow of -0.77, the BCF value for methanol can be estimated to be 0.2.
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 67-56-1: waste number U154 (Ignitable waste).

Section 14 - Transport Information

US DOT IATA RID/ADR IMO Canada TDG
Shipping Name: METHANOL METHANOL
Hazard Class: 3 3(6.1)
UN Number: UN1230 UN1230
Packing Group: II II
Additional Info: FLASHPOINT 11 C

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 67-56-1 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA

CERCLA Hazardous Substances and corresponding RQs
CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 67-56-1: acute, flammable.
Section 313
This material contains Methanol (CAS# 67-56-1, 99 0%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 67-56-1 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 67-56-1 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
T F
Risk Phrases:

R 11 Highly flammable.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 39/23/24/25 Toxic : danger of very serious
irreversible effects through inhalation, in contact
with skin and if swallowed.

Safety Phrases:

S 16 Keep away from sources of ignition - No
smoking.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 7 Keep container tightly closed.

WGK (Water Danger/Protection)

CAS# 67-56-1: 1
Canada - DSL/NDSL
CAS# 67-56-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D1B, D2B.
Canadian Ingredient Disclosure List
CAS# 67-56-1 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 67-56-1: OEL-ARAB Republic of Egypt:TWA 200 ppm (260 mg/m3);Ski
n OEL-AUSTRALIA:TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin OEL-BELGIU
M:TWA 200 ppm (262 mg/m3);STEL 250 ppm;Skin OEL-CZECHOSLOVAKIA:TWA 10
0 mg/m3;STEL 500 mg/m3 OEL-DENMARK:TWA 200 ppm (260 mg/m3);Skin OEL-
FINLAND:TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin OEL-FRANCE:TWA 200
ppm (260 mg/m3);STEL 1000 ppm (1300 mg/m3) OEL-GERMANY:TWA 200 ppm (2
60 mg/m3);Skin OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN9 OEL
-JAPAN:TWA 200 ppm (260 mg/m3);Skin OEL-THE NETHERLANDS:TWA 200 ppm (
260 mg/m3);Skin OEL-THE PHILIPPINES:TWA 200 ppm (260 mg/m3) OEL-POLA
ND:TWA 100 mg/m3 OEL-RUSSIA:TWA 200 ppm;STEL 5 mg/m3;Skin OEL-SWEDEN
:TWA 200 ppm (250 mg/m3);STEL 250 ppm (350 mg/m3);Skin OEL-SWITZERLAN
D:TWA 200 ppm (260 mg/m3);STEL 400 ppm;Skin OEL-THAILAND:TWA 200 ppm
(260 mg/m3) OEL-TURKEY:TWA 200 ppm (260 mg/m3) OEL-UNITED KINGDOM:TW
A 200 ppm (260 mg/m3);STEL 250 ppm;Skin OEL IN BULGARIA, COLOMBIA, JO
RDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM ch
eck ACGI TLV

Section 16 - Additional Information

MSDS Creation Date: 7/21/1999
Revision #11 Date: 10/21/2002

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.