Material Safety Data Sheet
Dichloromethane

ACC# 14930
Section 1 - Chemical Product and Company Identification

MSDS Name: Dichloromethane
Catalog Numbers: S80084, S80084-1, S80084-2SPEC, S80084HPLC, S80084SPEC, 23FD37500, BP1186-4, BP1186POP19, BP1186POP20, BP1186POP50, BP1186SS-19, BP1186SS-200, BP1186SS-28, BP1186SS-50, BP2608-100, D1381, D1384, D138SK4, D142-4, D142POP19, D142POP200, D142POP50, D142RS-19, D142RS115, D142RS200, D142RS28, D142RS50, D142SS-115, D142SS-200, D142SS-28, D142SS-50, D142SS19, D143-1, D143-4, D143J1, D143N219, D143NB219, D143POP19, D143POP200, D143POP28, D143POP50, D143POPN19, D143RS-19, D143RS115, D143RS200, D143RS28, D143RS50, D143SK-1, D143SK-4, D143SS-115, D143SS-200, D143SS-28, D143SS-50, D143SS19, D149-1, D149POP19, D149POP200, D149POP50, D149RS-19, D149RS-200, D149RS-50, D149SS19, D149SS200, D149SS50, D150-1, D150-4, D150J-4, D150SK-1, D150SK-4, D151-1, D151-4, D151POP19, D151POP200, D151POP50, D151RS-19, D151RS-200, D151RS-28, D151RS-50, D151RS115, D151SS-115, D151SS-200, D151SS-28, D151SS-50, D151SS19, D154-4, D1544LC, D35-1, D35-4, D37-1, D37-20, D37-200, D37-4, D37-500, D37200LC, D37FB-115, D37FB-19, D37FB-200, D37FB-50, D37POP19, D37POP200, D37POP50, D37POPB19, D37POPB200, D37POPB50, D37RB-115, D37RB-19, D37RB-200, D37RB-50, D37RS-115, D37RS-200, D37RS-28, D37RS-50, D37RS19, D37SK-4, D37SS-115, D37SS-200, D37SS-28, D37SS-50, D37SS19, NC9905243, NC9964976
Synonyms:
Methylene chloride; Methane dichloride; Methylene bichloride; Methylene dichloride; Dichloromethane; DCM.
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
201-796-7100
Emergency Number:
201-796-7100
For CHEMTREC assistance, call:
800-424-9300
For International CHEMTREC assistance, call:
703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
75-09-2 Methylene chloride >99.5 200-838-9

Hazard Symbols:
XN
Risk Phrases:
40

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: colorless liquid. This substance has caused adverse reproductive and fetal effects in animals. Potential cancer hazard. Warning! Causes eye and skin irritation. Causes respiratory tract irritation. Harmful if swallowed. May be harmful if inhaled. May cause central nervous system effects. Methylene chloride is metabolically converted to carbon monoxide after systemic absorption, which yields increased concentrations of carboxyhemoglobin in the blood. May cause kidney damage.
Target Organs: Blood, kidneys, heart, central nervous system, liver, lungs, pancreas.


Potential Health Effects
Eye: Contact with eyes may cause severe irritation, and possible eye burns.
Skin: May be absorbed through the skin. Causes irritation with burning pain, itching, and redness. Prolonged exposure may result in skin burns.
Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause carboxyhemoglobinemia.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause narcotic effects in high concentration. Vapors may cause dizziness or suffocation. May cause blood changes. Overexposure may cause an increase in carboxyhemoglobin levels in the blood. Can produce delayed pulmonary edema. Because of its high volatility, airborne concentrations of methylene c hloride can accumulate in poorly ventilated areas. Odor is a poor indi cator of possibly dangerous air concentrations of methylene chloride.
Chronic: Possible cancer hazard based on tests with laboratory animals. Prolonged or repeated skin contact may cause dermatitis. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. Chronic exposure may cause lung, liver, and pancreatic tumors. May cause conjunctivitis and/or corneal burns.

Section 4 - First Aid Measures


Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. No flash point in conventional closed tester, but forms flammable vapor-air mixtures in larger volumes and may be an explosion hazard in a confined space.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: 556 deg C ( 1,032.80 deg F)
Explosion Limits, Lower:13 vol %
Upper: 23 vol %
NFPA Rating: (estimated) Health: 2; Flammability: 1; Instability: 0

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Use only with adequate ventilation. Avoid breathing vapor or mist.
Storage: Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C. Keep away from active metals.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Methylene chloride 50 ppm TWA 2300 ppm IDLH 25 ppm TWA (8 hr.); 125 ppm STEL (15 min.); 12.5 ppm Action Level (see 29 CFR 19 10.1052)

OSHA Vacated PELs: Methylene chloride: 500 ppm TWA
Personal Protective Equipment
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: colorless
Odor: ethereal odor - chloroform-like
pH: Not available.
Vapor Pressure: 350 mm Hg @ 20 deg C
Vapor Density: 2.93 (Air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 40 deg C
Freezing/Melting Point:-97 deg C
Decomposition Temperature:Not available.
Solubility: Slightly soluble.
Specific Gravity/Density:1.33 (Water=1)
Molecular Formula:CH2Cl2
Molecular Weight:84.92

Section 10 - Stability and Reactivity


Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. May form explosive mixtures in atmospheres having high oxygen content.
Conditions to Avoid: Excess heat, attacks some plastics, rubber, and coatings, confined spaces, When no water is present, dichloromethane is not corrosive to metals. At high temperatures and in the presence of water (causing slow decomposition forming HCl), corrosion of iron, some stainless steels, copper and aluminum can occur..
Incompatibilities with Other Materials: Strong oxidizing agents, strong bases, chemically active metals.
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information


RTECS#:
CAS# 75-09-2: PA8050000
LD50/LC50:
CAS# 75-09-2:
Draize test, rabbit, eye: 162 mg Moderate;
Draize test, rabbit, eye: 10 mg Mild;
Draize test, rabbit, eye: 500 mg/24H Mild;
Draize test, rabbit, skin: 810 mg/24H Severe;
Draize test, rabbit, skin: 100 mg/24H Moderate;
Inhalation, mouse: LC50 = 14400 ppm/7H;
Inhalation, rat: LC50 = 52 gm/m3;
Oral, mouse: LD50 = 873 mg/kg;
Oral, rat: LD50 = 1600 mg/kg;
Carcinogenicity:
CAS# 75-09-2:
ACGIH: A3 - Animal Carcinogen
California: carcinogen; initial date 4/1/88
NIOSH: potential occupational carcinogen
NTP: Suspect carcinogen
OSHA: Possible Select carcinogen
IARC: Group 2B carcinogen
Epidemiology: There are few reports of injury despite widespread use of dichloromethane (ACGIH, 1991). Solvent abuse has led to death (Harbison, 1998).
Teratogenicity: Inhalation, rat: TCLo = 4500 ppm/24H (female 1-17 day(s) after conception) Effects on Newborn - behavioral.; Inhalation, rat: TCLo = 1250 ppm/7H (female 6-15 day(s) after conception) Specific Developmental Abnormalities - musculoskeletal system and urogenital system.
Reproductive Effects: Reproductive effects have occurred in experimental animals.
Neurotoxicity: No information available.
Mutagenicity: DNA inhibition: Human, Fibroblast = 5000 ppm/1H (Continuous).; Morphological transformation: Rat, Embryo = 160 umol/L.; DNA damage: Oral, rat = 1275 mg/kg.; Inhalation, mouse: TCLo = 2000 ppm/5H/2Y-C (Tumorigenic - Carcinogenic by RTECS criteria--Lungs, Thorax, or Respiration - Tumors).
Other Studies: See actual entry in RTECS for complete information.

Section 12 - Ecological Information


Ecotoxicity: Fish: Bluegill/Sunfish: 230mg/L; 24H; Static Fathead Minnow: 196mg/L; 96H; This chemical has a moderate potential to affect some aquatic organisms. It is resistant to biodegradation, and has a low potential to persist in the aquatic environment. 96-hr. EC50 (loss of equilibrium); Fathead minnow: 99mg/L; 96-hr. EC10: 66.3 mg/L. Bluegill sunfish: 96-hr. LC50=220 mg/L; Water flea: 24-hr. LC50=2270 mg/L; No observed effect level:1550 mg/L.
Environmental: Terrestrial: Expected to evaporate from near surface soil into the atmosphere; expected to leach. Aquatic: Primarily lost by evaporation to the atmosphere which should take several hours depending on wind and mixing conditions. Atmospheric: Will degrade by reaction with hydroxyl radicals with a half life of several months. . Dichloromethane is reported to completely biodegrade under aerobic conditions with sewage seed or activated sludge between 6 hours to 7 days. Not expected to bioconcentrate due to its low octanol/water coefficient.
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 75-09-2: waste number U080.

Section 14 - Transport Information

US DOT IATA RID/ADR IMO Canada TDG
Shipping Name: DICHLOROMETHANE METHYLENE CHLORIDE
Hazard Class: 6.1 6.1
UN Number: UN1593 UN1593
Packing Group: III III

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 75-09-2 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 75-09-2: Effective Date: 10/4/82; Sunset Date: 10/4/92
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA

CERCLA Hazardous Substances and corresponding RQs
CAS# 75-09-2: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 75-09-2: acute, chronic.
Section 313
This material contains Methylene chloride (CAS# 75-09-2, 99 5%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 75-09-2 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. CAS# 75-09-2 is listed as a Priority Pollutant under the Clean Water Act. CAS# 75-09-2 is listed as a Toxic Pollutant under the Clean Water Act.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 75-09-2 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
The following statement(s) is(are) made in order to comply with the California Safe Drinking Water Act: WARNING: This product contains Methylene chloride, a chemical known to the state of California to cause cancer. California No Significant Risk Level: CAS# 75-09-2: 200 ug/day NSRL (inhalation); 50 ug/day NSRL (except inhalation)

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:

R 40 Limited evidence of a carcinogenic effect.

Safety Phrases:

S 23 Do not inhale gas/fumes/vapour/spray.
S 24/25 Avoid contact with skin and eyes.
S 36/37 Wear suitable protective clothing and
gloves.

WGK (Water Danger/Protection)

CAS# 75-09-2: 2
Canada - DSL/NDSL
CAS# 75-09-2 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1B, D2A.
Canadian Ingredient Disclosure List
CAS# 75-09-2 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 75-09-2: OEL-AUSTRALIA:TWA 100 ppm (350 mg/m3);Carcinogen OEL-
AUSTRIA:TWA 100 ppm (360 mg/m3) OEL-BELGIUM:TWA 50 ppm (174 mg/m3);Ca
rcinogen OEL-CZECHOSLOVAKIA:TWA 500 mg/m3;STEL 2500 mg/m3 OEL-DENMAR
K:TWA 50 ppm (175 mg/m3);Skin;Carcinoge OEL-FINLAND:TWA 100 ppm (350
mg/m3);STEL 250 ppm (870 mg/m3) OEL-FRANCE:TWA 100 ppm (360 mg/m3);ST
EL 500 ppm (1800 mg/m3) OEL-GERMANY:TWA 100 ppm (360 mg/m3);Carcinoge
n OEL-HUNGARY:STEL 10 mg/m3;Carcinogen OEL-JAPAN:TWA 100 ppm (350 mg
/m3) OEL-THE NETHERLANDS:TWA 100 ppm (350 mg/m3);STEL 500 ppm OEL-TH
E PHILIPINES:TWA 500 ppm (1740 mg/m3) OEL-POLAND:TWA 50 mg/m3 OEL-RU
SSIA:TWA 100 ppm;STEL 50 mg/m3 OEL-SWEDEN:TWA 35 ppm (120 mg/m3);STEL
70 ppm (25 mg/m3);Skin OEL-SWITZERLAND:TWA 100 ppm (360 mg/m3);STEL
500 ppm OEL-THAILAND:TWA 500 mg/m3;STEL 1000 mg/m3 OEL-TURKEY:TWA 50
0 ppm (1740 mg/m3) OEL-UNITED KINGDOM:TWA 100 ppm (350 mg/m3);STEL 25
0 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL I
N NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV

Section 16 - Additional Information

MSDS Creation Date: 4/20/1999
Revision #5 Date: 2/20/2003

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.