Material Safety Data
Section 1 - Chemical Product and Company
MSDS Name: Chloroform
Catalog Numbers: AC95232184, S79960, S79960-1,
S79960HPLC-2, S79960SPEC-1, S79960SPEC-2, C2974LC, C297POP19, C297POP200,
C297POP50, C297RS115, C297RS200, C297RS28, C297RS50, C297SS115, C297SS19,
C297SS200, C297SS28, C297SS50, C29820LC, C298FB115, C298FB19, C298FB200,
C298FB50, C298J1, C298POP19, C298POP200, C298POP50, C298POPB19, C298POPB200,
C298POPB50, C298RB115, C298RB19, C298RB200, C298RB50, C298RB500, C298RS115,
C298RS19, C298RS200, C298RS28, C298RS50, C298SS-11, C298SS19, C298SS28, C605-1,
C605-4, C606POP19, C606POP200, C606POP50, C606RS115, C606RS200, C606RS28,
C606RS50, C606SS115, C606SS19, C606SS200, C606SS28, C606SS50
Synonyms: Formyl Trichloride; Methane Trichloride; Methenyl
Trichloride; Methyl Trichloride; Trichlormethan; Trichloroform;
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance,
For International CHEMTREC assistance, call:
Section 2 -
Composition, Information on Ingredients
Risk Phrases: 22 38 40 48/20/22
Section 3 - Hazards
Appearance: clear, colorless liquid. May cause central nervous system
depression. May cause cardiac disturbances. May cause cancer based on animal
studies. This substance has caused adverse reproductive and fetal effects in
animals. May be harmful if swallowed. Caution! Causes eye and
skin irritation. Causes digestive and respiratory tract irritation. Light
Target Organs: Blood, kidneys, heart, central
nervous system, liver, cardiovascular system, excretory system, reproductive
Potential Health Effects
Eye: Causes moderate eye irritation. Contact with
liquid causes immediate burning pain, tearing, and reddening of the conjunctiva.
Skin: Causes mild skin irritation. Prolonged or repeated
contact may dry/defat the skin and cause irritation. Absorption of liquid
through intact skin is possible and may cause sys temic poisoning if contact
with liquid is prolonged.
gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver
damage. May cause cardiac disturbances. Aspiration of material into the lungs
may cause chemical pneumonitis, which may be fatal. Possible aspiration hazard.
May cause hallucinations and distorted perceptions.
Inhalation: Inhalation of high concentrations may cause
central nervous system effects characterized by nausea, headache, dizziness,
unconsciousness and coma. May cause cardiac sensitization and possible failure.
Inhalation of large amounts may cause respiratory stimulation, followed by
respiratory depression, convulsions and possible death due to respiratory
paralysis. May be absorbed through the lungs. Causes irritation of the mucous
membrane and upper respiratory tract.
cancer hazard based on tests with laboratory animals. Prolonged or repeated skin
contact may cause dermatitis. May cause reproductive and fetal effects. Effects
may be delayed. Laboratory experiments have resulted in mutagenic effects.
Toxicity may be increased by exposure to alcohol, steroids, and ketones.
Prolonged exposure may cause liver, kidney, and heart damage.
Section 4 - First Aid
Eyes: Immediately flush eyes with plenty of water
for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get
Skin: Get medical aid. Flush skin with plenty
of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion: Do NOT induce
vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid
Inhalation: Get medical aid immediately.
Remove from exposure and move to fresh air immediately. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Causes cardiac sensitization to
endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use
adrenergic agents such as epinephrine or pseudoepinephrine. Persons with liver,
kidney, or central nervous system diseases may be at increased risk from
exposure to this product. Alcoholic beverage consumption may enhance the toxic
effects of this substance. Effects may be delayed.
Section 5 - Fire
Information: As in any fire, wear a self-contained breathing apparatus
in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective
gear. During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion. Use water spray to keep fire-exposed
containers cool. Substance is nonflammable. Vapors may be heavier than air. They
can spread along the ground and collect in low or confined areas. Containers may
explode when heated.
Extinguishing Media: Use extinguishing
media most appropriate for the surrounding fire. Do NOT get water inside
containers. Do NOT use straight streams of water. For small fires, use dry
chemical, carbon dioxide, or water spray. For large fires, use water spray, fog
or regular foam. Cool containers with flooding quantities of water until well
after fire is out.
Flash Point: Not available.
Temperature: Not available.
Explosion Limits, Lower:Not
Upper: Not available.
(estimated) Health: 2; Flammability: 0; Instability: 0
Section 6 -
Accidental Release Measures
Information: Use proper personal protective equipment as indicated in
Spills/Leaks: Absorb spill with inert material
(e.g. vermiculite, sand or earth), then place in suitable container. Avoid
runoff into storm sewers and ditches which lead to waterways. Clean up spills
immediately, observing precautions in the Protective Equipment section. Provide
ventilation. Approach spill from upwind.
Section 7 - Handling
Handling: Wash thoroughly after handling. Remove
contaminated clothing and wash before reuse. Use only in a well-ventilated area.
Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist,
or gas. Do not ingest or inhale. Store protected from light.
Storage: Do not store in direct sunlight. Store in a cool,
dry, well-ventilated area away from incompatible substances. Do not store near
alkaline substances. Separate from strong mineral acids.
Section 8 - Exposure
Controls, Personal Protection
Controls: Facilities storing or utilizing this material should be
equipped with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the permissible
||10 ppm TWA
||500 ppm IDLH
||50 ppm Ceiling; 240 mg/m3 Ceiling|
OSHA Vacated PELs:
Chloroform: 2 ppm TWA; 9.78 mg/m3 TWA Amylene: No OSHA Vacated PELs are listed
for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face protection regulations in 29
CFR 1910.133 or European Standard EN166.
appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent
Respirators: A respiratory protection program that
meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN
149 must be followed whenever workplace conditions warrant a respirator's use.
Section 9 - Physical
and Chemical Properties
Appearance: clear, colorless
Odor: sweet, fruity
odor - ethereal odor
pH: Not available.
160 mm Hg @ 20 deg C
Vapor Density: 4.12 (Air=1)
Rate:11.6 (Butyl acetate=1)
Viscosity: 0.58 cps @ 20 deg C
Boiling Point: 60.5-61.5 deg C
Decomposition Temperature:Not available.
Specific Gravity/Density:1.492 (Water=1)
Section 10 -
Stability and Reactivity
Stability: Stable at room temperature in closed containers under normal
storage and handling conditions. Light sensitive.
Avoid: High temperatures, incompatible materials, light.
Incompatibilities with Other Materials: Strong oxidizing agents,
aluminum, fluorine, magnesium, sodium potassium, lithium, caustics (e.g.
ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium
hydroxide), dinitrogen tetraoxide, sodium + methanol, potassium-tert-butoxide,
chemically active metals, Attacks some forms of plastics, rubbers, and
coatings., nitrogen tetroxide, acetone + alkali, disilane, perchloric acid +
phosphorus pentoxide, sodium methylate, triisopropylphosphine, sodium methoxide
Hazardous Decomposition Products: Hydrogen chloride,
carbon monoxide, carbon dioxide, chlorine, phosgene gas.
Polymerization: Will not occur.
Section 11 -
CAS# 67-66-3: FS9100000
CAS# 25377-72-4 unlisted.
Draize test, rabbit, eye: 148
Draize test, rabbit, eye: 20 mg/24H Moderate;
Draize test, rabbit,
skin: 500 mg/24H Mild;
Inhalation, rat: LC50 = 47702 mg/m3/4H;
mouse: LD50 = 36 mg/kg;
Oral, rat: LD50 = 695 mg/kg;
Skin, rabbit: LD50 =
ACGIH: A3 - Animal
California: carcinogen; initial date 10/1/87
NIOSH: potential occupational carcinogen
OSHA: Possible Select carcinogen
IARC: Group 2B
carcinogen CAS# 25377-72-4: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: Oral, rat: TDLo = 13832 mg/kg/2Y-C (Tumorigenic -
Carcinogen ic by RTECS criteria - Blood - leukemia).; Oral, mouse: TDLo = 127
gm/kg/92W-I (Tumorigenic - Carcinogenic by RTECS criteria - Liver - tumors).;
Oral, rat: TD = 98 gm/kg/78W-I (Tumorigenic - neoplastic by RTECS criteria -
Kidney, Ureter, Bladder - Kidney tumors and Endocrine - thyroid tumors).; Oral,
mouse: TD = 18 gm/kg/17W-I (Tumorigenic - neoplastic by RTECS criteria - Liver -
Teratogenicity: Oral, rat: TDL0 = 1260 mg/kg (female 6-15
day(s) after conception) Effects on Embryo or Fetus - fetotoxicity (except
death, e.g., stunted fetus) Specific Developmental Abnormalities -
musculoskeletal system.; Inhalation, rat: TCLo = 100 ppm/7H (female 6-15 day(s)
after conception) Specific Developmental Abnormalities - gastrointestinal system
and homeostasis.; Inhalation, mouse: TCLo = 100 ppm/7H (female 8-15 day(s) after
conception) Specific Developmental Abnormalities - craniofacial (including nose
Reproductive Effects: Inhalation, rat: TCLo = 30 ppm/7H
(female 6-15 day(s) after conception) Fertility - other measures of fertility.;
Inhalation, rat: TCLo = 300 ppm/7H (female 6-15 day(s) after conception)
Fertility - female fertility index (e.g. # females pregnant per # sperm positive
females; # females pregnant per # females mated) and post-implantation mortality
(e.g. dead and/or resorbed implants per total number of implants).
Neurotoxicity: No information available.
Inhibition: Human, HeLa cell = 19 mmol/L.; Sister Chromatid Exchange: Human,
Lymphocyte = 10 mmol/L.; Micronucleus Test: Oral, rat = 4 mmol/kg.; Unscheduled
DNA Synthesis: Oral, rat = 1 gm/kg.; Sister Chromatid Exchange: Hamster, Embryo
= 100 umol/L.
Other Studies: Open irritation test: Administration
onto the skin (rabbit) 10 mg/24H (Mild). Standard Draize Test: Administratio n
onto the skin (rabbit) = 500 mg/24H (Mild). Standard D raize Test:
Administration into the eye (rabbit) = 20 mg /24H (Moderate).
Section 12 -
Fish: Channel catfish: LC50 = 75 ppm; 96 Hr; Unspecified Rainbow trout: LC50 =
43.8 mg/L; 96 Hr; Static bioassay Fathead Minnow: LC50 = 129.0 mg/L; 96 Hr;
Static bioassay (pH = 7.6-8.3) Bluegill/Sunfish: LC50 = 100.0 mg/L; 96 Hr;
Static bioassay flea Daphnia: EC50 = 28.9 mg/L; 48 Hr; Static bioassay The
majority of the environmental releases from industrial uses are to the
atmosphere; releases to water and land will be primarily lost by evaporation and
will end up in the atmosphere. Release to the atmosphere may be transported long
distances and will photodegrade with a half-life of a few months. Spills and
other releases on land will also leach into the groundwater where it will reside
for long periods of time.
Environmental: Chloroform will not be
expected to bioconcentrate into the food chain but contamination of food is
likely due to its use as an extractant and its presence in drinking water.
Physical: No information available.
Other: No information
Section 13 - Disposal
Chemical waste generators
must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR
Parts 261.3. Additionally, waste generators must consult state and local
hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 67-66-3:
waste number U044.
Section 14 -
Section 15 -
CAS# 67-66-3 is listed on the TSCA
CAS# 25377-72-4 is listed on the TSCA inventory.
& Safety Reporting List
CAS# 67-66-3: Effective Date: 6/1/87; Sunset
Chemical Test Rules
None of the chemicals in this
product are under a Chemical Test Rule.
None of the
chemicals are listed under TSCA Section 12b.
TSCA Significant New Use
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding
CAS# 67-66-3: 10 lb final RQ; 4.54 kg final RQ
302 Extremely Hazardous Substances
CAS# 67-66-3: 10,000 lb TPQ
CAS # 67-66-3: acute, chronic. CAS # 25377-72-4: acute,
This material contains Chloroform (CAS#
67-66-3, 100%),which is subject to the reporting requirements of Section 313 of
SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 67-66-3 is
listed as a hazardous air pollutant (HAP). This material does not contain any
Class 1 Ozone depletors. This material does not contain any Class 2 Ozone
Clean Water Act:
CAS# 67-66-3 is listed as a Hazardous
Substance under the CWA. CAS# 67-66-3 is listed as a Priority Pollutant under
the Clean Water Act. CAS# 67-66-3 is listed as a Toxic Pollutant under the Clean
None of the chemicals in this product are
considered highly hazardous by OSHA.
CAS# 67-66-3 can be
found on the following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 25377-72-4 can be found on the
following state right to know lists: New Jersey.
statement(s) is(are) made in order to comply with the California Safe Drinking
Water Act: WARNING: This product contains Chloroform, a chemical known to
the state of California to cause cancer. California No Significant Risk Level:
CAS# 67-66-3: 20 ug/day NSRL (oral); 40 ug/day NSRL (inhalation)
Labeling in Accordance with EC Directives
R 22 Harmful if swallowed.
R 38 Irritating to
R 40 Limited evidence of a carcinogenic effect.
R 48/20/22 Harmful
: danger of serious damage to
health by prolonged exposure through
inhalation and if
S 36/37 Wear
suitable protective clothing and
CAS# 67-66-3: 3
CAS# 25377-72-4: No information
Canada - DSL/NDSL
CAS# 67-66-3 is listed on Canada's
CAS# 25377-72-4 is listed on Canada's DSL List.
This product has a WHMIS classification of D2A, D1B.
Canadian Ingredient Disclosure List
CAS# 67-66-3 is listed on the
Canadian Ingredient Disclosure List.
OEL-ARAB Republic of Egypt:TWA 10 ppm (50 mg/m3) OEL-
AUSTRALIA:TWA 10 ppm
(50 mg/m3);Carcinogen OEL-AUSTRIA:TWA 10 ppm (50
mg/m3) OEL-BELGIUM:TWA 10
ppm (49 mg/m3);Carcinogen JAN9 OEL-CZECHO
SLOVAKIA:TWA 10 mg/m3;STEL 20
mg/m3 OEL-DENMARK:TWA 2 ppm (10 mg/m3);
Carcinogen OEL-FINLAND:TWA 10 ppm (50
mg/m3);STEL 20 ppm;Skin;CAR OE
L-FRANCE:TWA 5 ppm (25 mg/m3);STEL 50 ppm (250
:TWA 10 ppm (50 mg/m3);Carcinogen JAN9
OEL-HUNGARY:STEL 10 mg/m3 OEL
-INDIA:TWA 10 ppm (50 mg/m3);Carcinogen
OEL-JAPAN:TWA 50 ppm (240 mg/
m3);Carcinogen OEL-THE NETHERLANDS:TWA 10 ppm
(50 mg/m3) OEL-THE PHI
LIPPINES:TWA 50 ppm (240 mg/m3) OEL-POLAND:TWA 50
WA 50 ppm OEL-SWEDEN:TWA 2 ppm (10 mg/m3);STEL 5 ppm (25
OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm (100 mg/m3)
ILAND:TWA 50 ppm (240 mg/m3) OEL-TURKEY:TWA 50 ppm (240 mg/m3)
NITED KINGDOM:TWA 2 ppm (9.9 mg/m3);Skin OEL IN BULGARIA, COLOMBIA,
ORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM
heck ACGIH TLV
Section 16 -
MSDS Creation Date:
Revision #7 Date: 9/11/2002
The information above is
believed to be accurate and represents the best information currently available
to us. However, we make no warranty of merchantability or any other warranty,
express or implied, with respect to such information, and we assume no liability
resulting from its use. Users should make their own investigations to determine
the suitability of the information for their particular purposes. In no event
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for lost profits or any special, indirect, incidental, consequential or
exemplary damages, howsoever arising, even if Fisher has been advised of the
possibility of such damages.