Material Safety Data
Section 1 - Chemical Product and Company
MSDS Name: Acetonitrile
Catalog Numbers: S70092ACS, S70092HPLC, A21-1, A21-20,
A21-200, A21-4, A211, A21FB115, A21FB19, A21FB200, A21FB50, A21POP19, A21POP200,
A21POP50, A21POPB19, A21POPB200, A21POPB50, A21RB115, A21RB19, A21RB200,
A21RB50, A21RS115, A21RS200, A21RS28, A21SS-115, A21SS-200, A21SS-28, A21SS-30,
A21SS-50, A21SS19, A9931, A993POP19, A993POP200, A993POP50, A993RS19, A993RS200,
A993RS50, A993SS19, A993SS200, A993SS50, A996-1, A996-4, A9964LC, A996N219,
A996NB219, A996POP19, A996POP200, A996POP50, A996POPN19, A996RS-115, A996RS-19,
A996RS-200, A996RS-28, A996RS-50, A996SS115, A996SS19, A996SS200, A996SS28,
A996SS50, A998-1, A998-4, A998212, A9984LC, A998N119, A998N219, A998NB219,
A998POP19, A998POP200, A998POP50, A998POPN19, A998RS115, A998RS19, A998RS200,
A998RS28, A998RS50, A998SK-1, A998SK-4, A998SK4LC, A998SS-115, A998SS-200,
A998SS-28, A998SS-30, A998SS-50, A998SS19, A999-4, BP1165-50, BP1170-4,
BP11704004, BP1170450, BP1170N119, BP1170N219, BP1170NB219, BP1170POP13,
BP1170POP19, BP1170POP20, BP1170POP50, BP1170POPN1, BP1170RS-1350, BP1170RS115,
BP1170RS19, BP1170RS200, BP1170RS28, BP1170RS50, BP1170SS-115, BP1170SS-200,
BP1170SS-28, BP1170SS-30, BP1170SS-50, BP1170SS135, BP1170SS19, BP24051,
BP24054, BP2405SK1, BP2405SK4, BP2600-100, FLBP1170RS20SP, NC9071789, NC9086431,
NC9708859, NC9833088, NC9927693, NC9958716, NC9979248, NC9995374, NC9998185,
O1034-500, XXA99820LI, XXA998U20LIN
Ethanenitrile; Ethyl nitrile; Methyl cyanide.
Fair Lawn, NJ 07410
For information, call: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
International CHEMTREC assistance, call: 703-527-3887
Section 2 -
Composition, Information on Ingredients
Symbols: XN F
Risk Phrases: 11 20/21/22 36
Section 3 - Hazards
Appearance: clear, colorless liquid. Flash Point: 6 deg C.
Warning! May cause central nervous system depression. May
cause liver and kidney damage. May cause reproductive and fetal effects.
Lachrymator (substance which increases the flow of tears). Hygroscopic (absorbs
moisture from the air). Metabolized to cyanide in the body, which may cause
headache, dizziness, weakness, unconsciousness, convulsions, coma and possible
Flammable liquid and vapor. Harmful if swallowed or absorbed through the skin.
Causes eye irritation. May cause skin and respiratory tract irritation. May be
harmful if inhaled.
Target Organs: Blood, kidneys, central
nervous system, liver, lungs.
Eye: Causes eye irritation.
Lachrymator (substance which increases the flow of tears). May produce
superficial reversible injury.
Skin: Causes mild skin
irritation. Harmful if absorbed through the skin. May be metabolized to cyanide
which in turn acts by inhibiting cytochrome oxidase impairing cellular
Ingestion: May cause gastrointestinal
irritation with nausea, vomiting and diarrhea. May cause effects similar to
those for inhalation exposure. May cause tissue anoxia, characterized by
weakness, headache, dizziness, confusion, cyanosis (bluish skin due to deficient
oxygenation of the blood), weak and irregular heart beat, collapse,
unconsciousness, convulsions, coma and death. May cause central nervous system
depression. Metabolism may release cyanide, which may result in headache,
dizziness, weakness, collapse, unconsciousness and possible death.
Inhalation: Aspiration may lead to pulmonary edema. Vapors
may cause dizziness or suffocation. Causes upper respiratory tract irritation.
May be metabolized to cyanide which in turns act by inhibiting cytochrome
oxidase impairing cellular respiration. May cause tissue anoxia, characterized
by weakness, headache, dizziness, confusion, cyanosis (bluish discoloration of
skin due to deficient oxygenation of the blood), weak and irregular heart beat,
collapse, unconsciousness, convulsions, coma and death.
Chronic: Prolonged or repeated skin contact may cause
dermatitis. Chronic inhalation and ingestion may cause effects similar to those
of acute inhalation and ingestion. May cause liver and kidney damage. May be
metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase
impairing cellular respiration. Animal studies have reported that fetal
effects/abnormalities may occur when maternal toxicity is seen. Laboratory
experiments have resulted in mutagenic effects. Exposure to small amounts of
cyanide compounds over long periods of time is reported to cause loss of
appetite, headache, weakness, nausea, dizziness, and symptoms of irritation of
the upper respiratory tract and eyes.
Section 4 - First Aid
Eyes: Immediately flush eyes with plenty of water
for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get
medical aid immediately. Do NOT allow victim to rub or keep eyes closed.
Skin: Get medical aid immediately. Immediately flush skin
with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes. Wash clothing before reuse.
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of
milk or water. Never give anything by mouth to an unconscious person. Get
medical aid immediately.
Inhalation: Get medical aid
immediately. Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Do NOT use mouth-to-mouth resuscitation.
Physician: Exposure should be treated as a cyanide poisoning. Effects
may be delayed. For methemoglobinemia, administer oxygen alone or with Methylene
blue depending on the methemoglobinemia concentration in the blood. May be
partially metabolized to cyanide in the body.
Always have a cyanide antidote kit on hand when working with cyanide compounds.
Get medical advice to use. Methylene blue, alone or in combination with oxygen
is indicated as a treatment in nitrite induced methemoglobinemia.
Section 5 - Fire
Information: Containers can build up pressure if exposed to heat and/or
fire. As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Water runoff can cause environmental damage. Dike and collect water used to
fight fire. Vapors may form an explosive mixture with air. During a fire,
irritating and highly toxic gases may be generated by thermal decomposition or
combustion. Use water spray to keep fire-exposed containers cool. Water may be
ineffective. Material is lighter than water and a fire may be spread by the use
of water. Flammable liquid and vapor. Approach fire from upwind to avoid
hazardous vapors and toxic decomposition products. Vapors are heavier than air
and may travel to a source of ignition and flash back. Vapors can spread along
the ground and collect in low or confined areas.
Media: For small fires, use dry chemical, carbon dioxide, water spray
or alcohol-resistant foam. Use water spray to cool fire-exposed containers.
Water may be ineffective. Do NOT use straight streams of water. For large fires,
use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool
containers with flooding quantities of water until well after fire is out.
Flash Point: 6 deg C ( 42.80 deg F)
Temperature: 524 deg C ( 975.20 deg F)
Lower:4.4 vol %
Upper: 16.00 vol %
Rating: (estimated) Health: 2; Flammability: 3; Instability: 0
Section 6 -
Accidental Release Measures
Information: Use proper personal protective equipment as indicated in
Spills/Leaks: Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately, observing
precautions in the Protective Equipment section. Remove all sources of ignition.
Absorb spill using an absorbent, non-combustible material such as earth, sand,
or vermiculite. Do not use combustible materials such as saw dust. Provide
ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray
may reduce vapor but may not prevent ignition in closed spaces. Approach spill
Section 7 - Handling
Handling: Remove contaminated clothing and wash
before reuse. Use only in a well-ventilated area. Ground and bond containers
when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get
in eyes, on skin, or on clothing. Empty containers retain product residue,
(liquid and/or vapor), and can be dangerous. Keep container tightly closed.
Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not
pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers
to heat, sparks or open flames.
Storage: Keep away from
heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly
closed container. Keep from contact with oxidizing materials. Store in a cool,
dry, well-ventilated area away from incompatible substances. Flammables-area.
Store protected from moisture.
Section 8 - Exposure
Controls, Personal Protection
Controls: Use explosion-proof ventilation equipment. Facilities storing
or utilizing this material should be equipped with an eyewash facility and a
safety shower. Use adequate general or local exhaust ventilation to keep
airborne concentrations below the permissible exposure limits.
||20 ppm TWA; skin - potential for cutaneous absorption
||20 ppm TWA; 34 mg/m3 TWA 500 ppm IDLH
||40 ppm TWA; 70 mg/m3
OSHA Vacated PELs:
Acetonitrile: 40 ppm TWA; 70 mg/m3 TWA
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin
Clothing: Wear appropriate protective clothing to
prevent skin exposure.
Respirators: A respiratory protection program
that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace conditions warrant a
Section 9 - Physical
and Chemical Properties
Appearance: clear, colorless
Odor: sweetish odor -
pH: Not available.
Vapor Pressure: 88.8 mm
Hg @ 25 deg C
Vapor Density: 1.42 (Air=1)
Rate:5.79 (Butyl acetate=1)
Viscosity: 0.36 cP 20 deg C
Boiling Point: 82 deg C @ 760 mm Hg
Point:-45 deg C
Decomposition Temperature:> 500 deg C
Section 10 -
Stability and Reactivity
Stability: Stable under normal temperatures and pressures.
to Avoid: Ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Oxidizing agents, reducing
agents, acids, bases, alkali metals, fluorine, nitric acid, perchlorates,
sulfuric acid, chlorosulfonic acid, oleum, dinitrogen tetraoxide, sulfites,
indium, moisture, Attacks some forms of plastics, rubbers, and coatings.,
nitrating agents, N-fluoro compounds (e.g. perfluorourea + acetonitrile),
lanthanide perchlorates, iron (III) perchlorate, 2-Cyano-2-propyl nitrate,
trichlorosilane, diphenyl sulfoxide.
Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and
toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will
Section 11 -
CAS# 75-05-8: AL7700000
Draize test, rabbit, eye: 100 uL/24H Moderate;
LC50 = 2693 ppm/1H;
Inhalation, rabbit: LC50 = 2828 ppm/4H;
rat: LC50 = 7551 ppm/8H;
Oral, mouse: LD50 = 269 mg/kg;
Oral, rabbit: LD50
= 50 mg/kg;
Oral, rat: LD50 = 2460 mg/kg;
Skin, rabbit: LD50 = >2
- Not Classifiable as a Human Carcinogen
volunteers were exposed for 4 hours at 40, 80, or 160 ppm acetonitrile. At 40
ppm, odor was detected, after which olfactory fatigue was noted. At this
concentratio n, 2 persons had no signs of response, including no apprec iable
blood or urinary cyanide or thiocyanate. The thi rd person experienced slight
tightness in the chest that evening. A sensation of cooling in the lungs was
observed and persisted for 24 hours. Traces of urinary thiocyanate w ere
Teratogenicity: See actual entry in RTECS for complete
Reproductive Effects: See actual entry in RTECS for
Neurotoxicity: No information available.
Mutagenicity: See actual entry in RTECS for complete information.
Other Studies: Open irritation test: Administration onto the skin
(rabbit) = 500 mg (Mild).
Section 12 -
Fish: Fathead Minnow: 1150 ppm; 24 Hr; TLm (hard water) Fathead Minnow: 1000
mg/L; 96 Hr; TLm (soft water) Bluegill/Sunfish: 1850 mg/L; 96 Hr; TLm (soft
water) Fathead Minnow: 1640 mg/L; 96 Hr; LC50 (flow-bioassay) Fathead Minnow:
1640 mg/L; 96 Hr; EC50 (flow-bioassay) No data available.
Environmental: Estimated Koc value = 16. Acetonitrile is expected to
weakly adsorb to most soils based on the Koc value. Volitization from soil
surfaces and leaching into ground water is expected to be significant. Estimated
BCF value = 0.3. This value indicates that acetonitrile will not significantly
bioconcentrate in aquatic organisms or adsorb to suspended solids and sediments
in water. Acetonitrile is unreactive towards photochemically-generated free
radicals and direct photolysis in the gaseous phase.
Section 13 - Disposal
Chemical waste generators
must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR
Parts 261.3. Additionally, waste generators must consult state and local
hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 75-05-8:
waste number U003 (Ignitable waste, Toxic waste).
Section 14 -
Section 15 -
CAS# 75-05-8 is listed on the TSCA
Health & Safety Reporting List
Effective Date: 10/4/82; Sunset Date: 10/4/92
None of the chemicals in this product are under a Chemical Test
None of the chemicals are listed under TSCA
TSCA Significant New Use Rule
None of the chemicals
in this material have a SNUR under TSCA.
Hazardous Substances and corresponding RQs
CAS# 75-05-8: 5000 lb final
RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous
None of the chemicals in this product have a TPQ.
CAS # 75-05-8: acute, chronic, flammable.
This material contains Acetonitrile (CAS# 75-05-8, 100%),which is
subject to the reporting requirements of Section 313 of SARA Title III and 40
CFR Part 373.
Clean Air Act:
CAS# 75-05-8 is listed as a hazardous
air pollutant (HAP). This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
None of the chemicals in this product are listed as Hazardous
Substances under the CWA. None of the chemicals in this product are listed as
Priority Pollutants under the CWA. None of the chemicals in this product are
listed as Toxic Pollutants under the CWA.
None of the
chemicals in this product are considered highly hazardous by OSHA.
CAS# 75-05-8 can be found on the following state right to
know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product
European Labeling in Accordance with EC
11 Highly flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36 Irritating to eyes.
S 16 Keep away from sources of ignition - No
36/37 Wear suitable protective clothing and
CAS# 75-05-8: 2
Canada - DSL/NDSL
75-05-8 is listed on Canada's DSL List.
Canada - WHMIS
product has a WHMIS classification of B2, D1B, D2B.
CAS# 75-05-8 is listed on the Canadian Ingredient
CAS# 75-05-8: OEL-ARAB Republic of
Egypt:TWA 40 ppm (70 mg/m3);Skin
OEL-AUSTRALIA:TWA 40 ppm (70 mg/m3);STEL 60
ppm ;Skin OEL-AUSTRIA:TW
A 40 ppm (70 mg/m3) OEL-BELGIUM:TWA 40 ppm (67
mg/m3);STEL 60 ppm (10
mg/m3);Skin OEL-DENMARK:TWA 40 ppm (70 mg/m3);STEL 60
ppm (10 mg/m3)
OEL-FINLAND:TWA 40 ppm (70 mg/m3);STEL 60 ppm (10 mg/m3)
:TWA 40 ppm (70 mg/m3) OEL-GERMANY:TWA 40 ppm (70 mg/m3)
:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN9 OEL-THE NETHERLANDS:TWA 40
(70 mg/m3) OEL-THE PHILIPPINES:TWA 40 ppm (70 mg/m3) OEL-RUSSIA:STE
10 mg/m3 OEL-SWITZERLAND:TWA 40 ppm (70 mg/m3);STEL 80 ppm ;Skin
EL-TURKEY:TWA 40 ppm (70 mg/m3) OEL-UNITED KINGDOM:TWA 40 ppm (70
m3);STEL 60 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH
TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
Section 16 -
MSDS Creation Date:
Revision #8 Date: 10/16/2002
The information above is
believed to be accurate and represents the best information currently available
to us. However, we make no warranty of merchantability or any other warranty,
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