The news article explores a study done which explores the angiogenesis of blood vessels. Angiogenesis is the formation of new vessels, and the study pinpoints the protein, v3 integrin, as the influential protein in the process of angiogenesis. The article continues to suggest that knowledge of this protein can help doctors know whether patientsę blood vessels are forming as expected, without using invasive techniques.

1) What specific claim(s) does the news article make about the study? That is, what did the news article say was discovered? For each claim, indicate if the original paper actually makes that claim.

The news article suggests that the study found a way to determine whether blood vessels were formed in patients, through radioactive tagging. It also found that the protein, v3 integrin, was linked to the process of angiogenesis.

2) Most technical papers have a "Conclusions" section (often labeled as such). Find this section. Are the items which the original authors highlighted as conclusions of their study discussed in the news article? Indicate "yes" or "no", giving your evidence.

This paper lacks a ņconclusionî section, but discusses the 110In-RP748 radioactive tag of the v3 integrin and itęs which the news article discusses briefly.

3) Most technical papers will describe the uncertainty around their conclusions and discoveries, often discussed in a section labeled "Discussion." Does the original paper describe the degree of confidence the scientists have in their discoveries? If so, describe this, and indicate whether or not the news article also discusses the degree of uncertainty.

The discussion section of the scientific article describes how the SPECT imaging worked successfully in the myocardial imaging. The scientists are still unsure of the duration of the expression of the v3 integrin expression and the activation that will be required for angiogenesis

4) It is the job of the news reporter to make whatever item they are reporting on relevant to some larger issue or set of issues; in contrast, a technical paper is often much more focused and may not deal with broader implications of the work. Do you find examples of the reporter discussing "broader implications" not present in the original paper? If so, describe them. Additionally, if so, indicate whether you (as a reader) can see that this broader implication actually does follow from the conclusions of the study.

The reporter focuses more on the impact of the studiesę findings on humans and the possibilities that may be offered to scientific community. The articlesę focus is directed towards helping stimulate the hearts of patients who have undergone surgery to produce new blood vessels, as well as tracking the activity of the blood vessels through special imaging techniques that would be less invasive than current techniques.

5) In some technical paper the original scientists might describes previous contradictory work of previous research (often in the "Introduction"), which they presumably consider their new work has overturned. If so, does the news article reflect that this study has resulted in the rejection of a previous hypothesis?

Studies have been performed on myocardial angiogenesis, and techniques of gene therapy and revascularization. Imaging strategies have not been as successful in the evaluation of myocardial angiogenesis however, with the identification of the v3 integrin and its influence on angiogenesis of blood vessels, scientists have a target for imaging.

6) Journalists very often couch science news items as "debates between equal sides", even if the weight of the evidence is not equal. Does the news article discuss alternative hypotheses that are not mentioned in the original paper? If so, does the news article give a measure of what degree of evidential support exists for either of the alternative models?

This news article puts a humanistic spin on the paper. While the scientific article focuses on the success of the radioactive tagging of the v3 integrin protein, the news article focuses strongly on the ways in which doctors can benefit from the protein and how heart patients may one day be treated without using invasive techniques.